Show simple item record

dc.contributor.authorBlevins, Jennifer Susanneen
dc.date.accessioned2014-03-14T20:19:50Zen
dc.date.available2014-03-14T20:19:50Zen
dc.date.issued2000-07-28en
dc.identifier.otheretd-12062000-151204en
dc.identifier.urihttp://hdl.handle.net/10919/29947en
dc.description.abstractObstructive sleep apnea (OSA) is estimated to affect 2 to 4 percent of the adult population (Young T 1993, Skomro and Kryger 1999). However, an estimated 80 to 90 percent of adults with moderate to severe OSA may be clinically undiagnosed. Identification of those at risk and their subsequent diagnosis is, obviously, of great concern to clinicians. This investigation included three distinct research aims, which were the following: (1): In order to establish reliability of hemodynamic measures to be used during exercise testing, a study was conducted on the acetylene single-breath cardiac output (Qc) technique in 15 healthy subjects. This was completed in order to establish reliability of exercise Qc and total peripheral resistance (TPR), these responses could then be investigated acutely in the context of evaluating the relation of these measures to markers of disease in OSA patients. (2): The primary research aim was to describe the extent to which graded exercise testing may reveal abnormalities in hemodynamic function in obstructive sleep apnea (OSA) patients, particularly with respect to cardiac output (Qc), mean arterial pressure (MAP), and TPR that may be related to polysomnography (PSG) markers of OSA severity. Cardiorespiratory and hemodynamic responses that were evaluated included the following: peak oxygen consumption (VO2pk), end-tidal carbon dioxide production (PETCO2), end-tidal oxygen pressure (PETO2), heart rate (HR), blood pressure (systolic = SBP and diastolic = DBP), rate pressure product (RPP), TPR and its derivatives including MAP and Qc, in OSA patients. A global biochemical marker of vascular function, 24-hour urinary nitrite/ nitrate elimination was also determined for each patient. (3): The last aim was included in order to provide qualitative information concerning treatment, subjective sleep and daytime function, and physical activity levels of the OSA patients in this investigation as well as to give insights into the special challenges and potential for doing trials involving nCPAP and physical exercise training with OSA patients. Results from this study can be used to improve clinical evaluation procedures as well as to better understand underlying mechanisms relative to the link between cardiovascular disease and OSAen
dc.publisherVirginia Techen
dc.relation.haspartjsbdissertationfulltext.pdfen
dc.relation.haspartVITA.pdfen
dc.relation.haspartFinalTitlepage.pdfen
dc.relation.haspartTableofContents.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectExerciseen
dc.subjectobstructive sleep apneaen
dc.subjecthemodynamic functionen
dc.titleThe relationship between markers of disease severity in obstructive sleep apnea patients and hemodynamic and respiratory function during graded exercise testingen
dc.typeDissertationen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.description.degreePh. D.en
thesis.degree.namePh. D.en
thesis.degree.leveldoctoralen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.disciplineHuman Nutrition, Foods, and Exerciseen
dc.contributor.committeechairHerbert, William G.en
dc.contributor.committeememberCross, Lawrence H.en
dc.contributor.committeememberGregg, John M.en
dc.contributor.committeememberZedalis, Donalden
dc.contributor.committeememberBos, Ronald R.en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-12062000-151204/en
dc.date.sdate2000-12-06en
dc.date.rdate2002-01-10en
dc.date.adate2001-01-10en


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record