Effect of Fenoldopam on Renal Function in Normal Dogs Following Nephrotomy
|dc.description.abstract||Objective: To evaluate the effect of fenoldopam on renal function in normal dogs subjected to bisection nephrotomy. In addition, effects of bisection nephrotomy on renal function in normal dogs were evaluated. |
Study Design: Controlled, randomized, blinded experiment
Sample Population: Sixteen mixed breed adult dogs
Methods: Dogs were paired for sex, body weight, and approximate age and were assigned to one of two groups: fenoldopam (F) or placebo (P). Baseline glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), urinalysis (UA), and urine culture were performed prior to surgery. A left bisection nephrotomy was performed via a standard midline celiotomy. Dogs in Group F received perioperative intravenous infusion of fenoldopam (0.1 Ã¬g/kg/min) for 90 minutes; dogs in Group P received 0.9 % saline (equivalent volume/kg) for 90 minutes. Body temperature, heart rate, respiration, direct arterial blood pressure, and urine volume were recorded during anesthesia. Renal function was assessed by measuring SCr, BUN, and GFR based on quantitative renal scintigraphy using 99mTc-DTPA at 1, 21, and 42 days after surgery.
Results: There was no significant difference between groups in physiologic parameters assessed. There was no significant difference in GFR, BUN, or SCr between groups or between operated or control kidneys.
Conclusions: Bisection nephrotomy in normal dogs with renal arterial occlusion of 15 minutes and a simple continuous capsular closure does not adversely affect renal function.
Clinical Relevance: Further study investigating perioperative effects of fenoldopam in dogs with existing renal dysfunction is indicated. Bisection nephrotomy, as described in this study, does not decrease renal function as measured by BUN, SCr, or GFR.
|dc.rights||I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.||en_US|
|dc.subject||Glomerular Filtration Rate||en_US|
|dc.title||Effect of Fenoldopam on Renal Function in Normal Dogs Following Nephrotomy||en_US|
|dc.contributor.department||Veterinary Medical Sciences||en_US|
|dc.description.degree||Master of Science||en_US|
|thesis.degree.name||Master of Science||en_US|
|thesis.degree.grantor||Virginia Polytechnic Institute and State University||en_US|
|thesis.degree.discipline||Veterinary Medical Sciences||en_US|
|dc.contributor.committeechair||Waldron, Don R.||en_US|
|dc.contributor.committeemember||Barber, Donald L.||en_US|
|dc.contributor.committeemember||Forrester, S. Dru||en_US|
|dc.contributor.committeemember||Wilcke, Jeffrey R.||en_US|
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