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dc.contributor.authorDrew, Christopher W.en_US
dc.description.abstractThe majority of the physical properties of tissue depend directly on the interstitial or intracellular concentration of water within the epidermal and dermal layers. The relationship between skin constituent concentrations, such as water and protein, and the mechanical and optical properties of human skin is important to understand its complex nature. Localized mechanical loading has been proven to alter optical properties of tissue, but the mechanisms by which it is accomplished have not been studied in depth. In this thesis, skinâ s complex nature is investigated experimentally and computationally to give us better insight on how localized mechanical loading changes tissues water content and its optical properties. Load-based compression and subsequent increased optical power transmission through tissue is accomplished to explore a relationship between localized mechanical loading and tissue optical and mechanical properties. Using Optical Coherence Tomography (OCT), modification of optical properties, such as refractive index, are observed to deduce water concentration changes in tissue due to mechanical compression. A computational finite element model is developed to correlate applied mechanical force to tissue strain and water transport. Comprehensive understanding of the underlying physical principles governing the optical property changes within skin due to water concentration variation will enable future development of applications in the engineered tissue optics field.en_US
dc.publisherVirginia Techen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectWater Contenten_US
dc.subjectFinite Elementen_US
dc.subjectMechanical Loadingen_US
dc.titleMechanical Loading for Modifying Tissue Water Content and Optical Propertiesen_US
dc.contributor.departmentMechanical Engineeringen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
dc.contributor.committeechairRylander, Christopher G.en_US
dc.contributor.committeememberWest, Robert L. Jr.en_US
dc.contributor.committeememberWang, Geen_US

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