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dc.contributor.authorHorowitz, Farrah B.en_US
dc.date.accessioned2014-03-14T20:38:44Z
dc.date.available2014-03-14T20:38:44Z
dc.date.issued2009-05-06en_US
dc.identifier.otheretd-05262009-142403en_US
dc.identifier.urihttp://hdl.handle.net/10919/33275
dc.description.abstractA blind, placebo â controlled clinical trial was performed to evaluate the postoperative analgesic effect of topically administered, intraoperative, epidural morphine (Duramorphâ ¢) and intramuscular infiltration of the incision site with bupivacaine prior to closure of the skin in dogs undergoing hemilaminectomy for Hansen type I Intervertebral Disk Disease (IVDD). Thirty-three dogs were randomly allocated into four treatment groups: epidural Duramorphâ ¢ with incisional bupivacaine (DUR/BUP), epidural saline with incisional bupivacaine (SAL/BUP), epidural Duramorphâ ¢ with incisional saline (DUR/SAL), and epidural saline with incisional saline (SAL/SAL). All dogs were premedicated with a standard protocol and were anesthetized with propofol and isoflurane. After surgery, scores were assigned using a visual analog scale (VAS) for both pain and sedation and a composite pain scale (CPS). In addition, a von Frey anesthesiometer was used to determine pain thresholds at 1 cm and 3 cm from the surgical incision line (primary hyperalgesia) as well as on the lateral aspect of the stifle (secondary hyperalgesia). Assessments were carried out at fixed intervals over the 48 hour postoperative period. Significant differences were found between those groups treated with the epidural Duramorphâ ¢ and those that received epidural saline. Those dogs in the DUR/BUP and DUR/SAL groups exhibited lower von Frey pain thresholds and higher VAS and CPS scores than the SAL/BUP and SAL/SAL groups. The administration of bupivacaine had no significant effect on any measured outcome. The authors conclude that topically administered epidural Duramorphâ ¢ and intramuscular incisional bupivacaine do not enhance analgesia following hemilaminectomy in the dog.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartThesisFinal.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectDogen_US
dc.subjectHemilaminectomyen_US
dc.subjectIVDDen_US
dc.subjectAnalgesiaen_US
dc.titleEvaluation of epidural morphine and incisional bupivacaine for analgesia following hemilaminectomy in the dogen_US
dc.typeThesisen_US
dc.contributor.departmentVeterinary Medical Sciencesen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineVeterinary Medical Sciencesen_US
dc.contributor.committeechairWaldron, Don R.en_US
dc.contributor.committeememberLanz, Otto I.en_US
dc.contributor.committeememberHarper, Tisha A.en_US
dc.contributor.committeememberBerry, Stephanie H.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-05262009-142403/en_US
dc.date.sdate2009-05-26en_US
dc.date.rdate2009-06-23
dc.date.adate2009-06-23en_US


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