Show simple item record

dc.contributor.authorRivera, Corban G.en_US
dc.date.accessioned2014-03-14T20:40:06Z
dc.date.available2014-03-14T20:40:06Z
dc.date.issued2005-05-31en_US
dc.identifier.otheretd-06162005-140525en_US
dc.identifier.urihttp://hdl.handle.net/10919/33604
dc.description.abstractOur goal is to investigate protein networks conserved between different organisms. Given the protein interaction networks for two species and a list of homologous pairs of protein in the two species, we propose a model for measuring whether two subnetworks, one in each protein interaction network, are conserved. Our model separately measures the degree of conservation of the two subnetworks and the quality of the edges in each subnetwork. We propose an algorithm for finding pairs of networks, one in each protein interaction network, with high conservation and high quality. When applied to publicly-available protein-protein interaction data and gene sequences for baker's yeast and fruit fly, our algorithm finds many conserved networks with a high degree of functional enrichment. Using our method, we find many conserved protein interaction networks involved in functions such as DNA replication, protein folding, response to heat, protein serine/threonine phosphatase activity, kinase activity, and ATPase activity.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartetd.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectOrthologuesen_US
dc.subjectProtein-Protein Interactionen_US
dc.subjectSpecies Hoppingen_US
dc.subjectConserved Networksen_US
dc.titleIdentifying Evolutionarily Conserved Protein Interaction Networksen_US
dc.typeThesisen_US
dc.contributor.departmentComputer Scienceen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineComputer Scienceen_US
dc.contributor.committeechairMurali, T. M.en_US
dc.contributor.committeememberZhang, Liqingen_US
dc.contributor.committeememberPotts, Malcolmen_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06162005-140525/en_US
dc.date.sdate2005-06-16en_US
dc.date.rdate2005-07-15
dc.date.adate2005-07-15en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record