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dc.contributor.authorKarkare, Sampada S.en_US
dc.date.accessioned2014-03-14T20:44:52Z
dc.date.available2014-03-14T20:44:52Z
dc.date.issued2007-08-30en_US
dc.identifier.otheretd-09062007-000547en_US
dc.identifier.urihttp://hdl.handle.net/10919/34945
dc.description.abstractThrough our continuing search for anticancer agents from Madagascar rainforests as a part of International Cooperative Biodiversity Group (ICBG), we received two extracts which were active against the A2780 human ovarian cancer cell line and hence were selected for further fractionation. Six compounds were isolated from these extracts. The structure elucidation and characterization of these compounds was carried out using mass spectrometry and 1D and 2D NMR techniques. The bioassay-guided fractionation of Roupellina (Strophanthus) boivinii yielded three new and one known cardenolide glycosides. The structure of the known cardenolide glycoside was determined after comparison of NMR data to that found in literature for digitoxigenin 3-O-β-D-glucopyranosyl-(1â 4)-α-L-acofriopyranoside. All four compounds exhibited good antiproliferative activity on the A2780 bioassay. The fractionation of the extract of Grewia sp. led to the isolation of one new and one known triterpenoid. The known triterpenoid was identified as 7β-hydroxy-23-deoxojessic acid and its structure was confirmed by comparison of its 1D and 2D NMR data to that found in literature.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartSupporting_information_chap_2.pdfen_US
dc.relation.haspartAbbreviations.pdfen_US
dc.relation.haspartThesis-chap_1.pdfen_US
dc.relation.haspartAcknowledgements.pdfen_US
dc.relation.haspartThesis-chap_4.pdfen_US
dc.relation.haspartThesis-chap_2.pdfen_US
dc.relation.haspartFigures.pdfen_US
dc.relation.haspartTables.pdfen_US
dc.relation.haspartContents.pdfen_US
dc.relation.haspartSchemes.pdfen_US
dc.relation.haspartTitle_abstract.pdfen_US
dc.relation.haspartThesis-chap_5.pdfen_US
dc.relation.haspartSupporting_information_chap_3.pdfen_US
dc.relation.haspartThesis-chap_3.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectStrophanthusen_US
dc.subjecttriterpenoidsen_US
dc.subjectGrewia sp.en_US
dc.subjectRoupellinaen_US
dc.subjectGrewiaen_US
dc.subjectboivinideen_US
dc.subjectcardenolide glycosidesen_US
dc.subjectA2780en_US
dc.subjectnatural productsen_US
dc.titleIsolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforestsen_US
dc.typeThesisen_US
dc.contributor.departmentChemistryen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberBrewer, Karen J.en_US
dc.contributor.committeememberCarlier, Paul R.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09062007-000547/en_US
dc.date.sdate2007-09-06en_US
dc.date.rdate2008-10-31
dc.date.adate2007-10-31en_US


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