Synthesis of some compounds of possible carcinogenic activity
Borkovec, Alexej B
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The campaign against cancer has hardly any counterpart in the history ot all the natural sciences, and there is hardly a branoh ot the natural sciences which has not been mobilized in this veritable crusade. It we inquire about the role of chemistry, and more specitically that of organic ohemistry in this movement, we should probably start with the year 1775 when Peroival Plott pointed out the possible connection between cancer, occupational disease of chimney sweepers, and soot. However, it was almost 150 years later when Passey' (1) oould prove this hypothesis by applying the ethereal extract of soot to the skin or a mouse and producing a malignant tumor on its back. Rather than attempting to depict historically all the contributions of organic chemists, it seems to be more important to inquire what is expected in our times ot the organio chemist, and what is the nature of his contribution which might ultimately help to solve the problem of cancer. Obviously, there is no one simple, straight forward answer to this question, yet an attempt can be made to generalize, and then a seemingly simple reply can be formulated. What is necessary is a clearer and deeper insight into the realm of organic compounds and reactions, and, specifically a better knowledge of some speoial fields of' organic ohemisty, namely the field of poly-nuclear hydrocarbons.
- Doctoral Dissertations