Studies on the structural organization of Golgi complex
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Goigi complex is a multi-compartmental organelle involved in posttranslational modification and sorting of secretory proteins. We have characterized the distribution in Vero cells of three Golgi cisternal membrane proteins, Sialyltransferase (SialyIT, tansGolgi/TGN), galactosyltransferase(GalT, trans-GolgiffGN), and Nacetylglucosametransferase-l (GlcNAcT-I, medial-Golgi), during the process of Golgi disassembly and reassembly following the addition or removal of drugs. After 1 h nocodazole (microtubule depolymerizer) treatment, SialylT and GalT were found in scattered punctate structures that increased in number over time as less and less of these proteins were found perinuclearly.
- Doctoral Dissertations