Acid-base regulation during exercise in the horse
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Effects of fat adaptation and NaHC03 supplementation on acid-base homeostasis were quantitated during repeated sprint exercise in horses. Contribution of strong ions ([SID]), Pco2, and weak electrolytes ([Atot]) to changes in plasma [H+] and the role of erythrocytes in acid-base balance were examined at rest and during exercise. Effects on plasma glucose and blood lactate [Lac-] concentrations due to sample handling were also assessed.
During exercise, blood [Lac-] was higher when horses received NaHC03 compared to water prior to exercise (P=0.0024), and in fat adapted horses compared to horses fed a control diet (P=O.0240). Blood [Lac-] was higher in fat adapted horses given NaHC03 compared to other diet/treatment combinations (P=O.0276). Plasma [SID] was higher during exercise when horses were given NaHC03 compared to plain water (P=O.0054), which contributed to decreasing [H+] and increasing [HC03-] during exercise (P=O.0001). Plasma Pco2 contributed less to increasing plasma [H+] during exercise in fat-adapted horses compared to horses fed the control diet (P=O.0282). Intraerythrocyte [SID] decreased (P=O.0160) and [Atod increased (P=O.0002) which contributed to increasing [H+] within the cell (P=O.0228).
- Doctoral Dissertations