Effects of Î±1-receptor blockade on the hemodynamic responses to exercise in young normotensives and hypertensives
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The purpose of this study was to determine if Î±1- adrenergic receptor blockade alters the hemodynamic response to exercise in young (<25 yr) male adult borderline hypertensives differently than in young normotensives. Five hypertensive (HTN, MAP>105 mmHg) and 7 normotensive (NTN, MAP<95 mmHg) college-age males underwent two 30 min bouts of cycle ergometry exercise at 50% V02Pk in a warm (25Â°C, 50% rh) environment; one bout occurred followed Î±1-receptor blockade with prazosin (HTN-Î±, NTN-Î±) and the other following placebo administration (HTN-p, NTN-p). At rest, HTN-p exhibited an elevated cardiac output (Q, p=.024) and MAP (p=.007). Resting Q was similar for HTN-Î± and NTN-Î±. Resting heart rate (HR) was elevated more in HTN-Î± than NTNÎ± (p=.013) and not different for placebo. Resting and exercise forearm blood flows were similar between groups and altered similarly with prazosin. Exercise resulted in greater (p=.035) Q for HTN vs NTN (HTN-u > NTN-Î±; HTN-p = NTN-p). HR was higher (p=.043) with prazosin for both groups. Regardless of drug treatment, MAP was stable for NTN while it declined after 10 min of exercise in HTN. Rectal temperatures rose above baseline after 10 min. since Q was similar between groups with placebo but not with Î±1- blockade, and FBF, MAP, and HR were similarly altered between drug trials, it was concluded that young male hypertensives have an elevated blood pressure due to an elevated Q. In this group, Î±1-blockade may reduce Q by reducing central venous return.
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