The late Mississippian carbonates in the Appalachian Basin, U.S.A., were deposited on a huge, south-facing ramp during long-term Mississippian transgression that formed the Mississippian supersequence. The St. Louis- to Glen Dean interval consists of up to twelve fourth-order depositional sequences (300 to 400 k.y. average duration). The sequences (a few meters to over a hundred meters thick) consist of eolianites, lagoonal carbonate muds, ooid shoals, and skeletal banks, and open marine skeletal wackestone and basinal marion the ramp-slope and basin margin. Sequence boundaries are at the top of prograding red-beds, eolianites, and shoal water facies on the ramp, and beneath lowstand sand bodies and quartzose calcisiltite wedges on the ramp margin and slope. Maximum flooding surfaces are difficult to map regionally, therefore it is difficult to separate the TST from the HST of these fourth-order sequences.