Show simple item record

dc.contributor.authorHill, James E.en_US
dc.date.accessioned2014-03-14T21:38:21Z
dc.date.available2014-03-14T21:38:21Z
dc.date.issued1977-05-15en_US
dc.identifier.otheretd-06122010-020304en_US
dc.identifier.urihttp://hdl.handle.net/10919/43247
dc.description.abstractDiets containing 5.0% excess phenylalanine; 6.0% excess protein (gelatin), and limited in tryptophan (75mg/lOOg) and/or vitamin E (O.lmg/IOOg) were fed to male rats during gestation and lactation. Addition of 5.0% phenylalanine result in a greater incidence of cataract than studies previously reported with diets limited in tryptophan and vitamin E alone, or a single supplementation of Vitamin E (40.0.mg/lOOg). Supplementation with tryptophan (500mg/lOOg) and vitamin E (40.0mg/100g) prevented cataract formation. Replacing the 5.0% excess phenylalanine and 6.0% excess protein (gelatin) with an equivalent of a balanced free amino acid mixture prevented cataract formation in the group supplemented with vitamin E alone. Addition of balanced free amino acids resulted in decreased fertility, pup survival, and increased diuresis. Supplementation with vitamin E (40.0mg/lOOg) alone prevented these effects. Urinary excretions of keto acid (phenylpyruvate), nitrogen, urea, and creatinine were examined during the 7-l4th days of gestation. Amino acid analysis were performed on plasma and soluble lens hornogenates from young progeny. Protein separations of soluble lens homogenates from young progeny were obtained. Analysis of these parameters did not indicate distinct differences between cataractous and noncataractous groups.en_US
dc.format.mediumBTDen_US
dc.publisherVirginia Techen_US
dc.relation.haspartLD5655.V855_1977.H55.pdfen_US
dc.subjectvisual impairmenten_US
dc.subject.lccLD5655.V855 1977.H55en_US
dc.titleCataract formation in young rats as a consequence of maternal diets containing excess phenylalanine and low in tryptophan and/or vitamin E.en_US
dc.typeThesisen_US
dc.contributor.departmentHuman Nutrition and Foodsen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineHuman Nutrition and Foodsen_US
dc.contributor.committeememberDriskell, Judy A.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-06122010-020304/en_US
dc.contributor.committeecochairBunce, George Edwinen_US
dc.contributor.committeecochairRitchey, Sanford J.en_US
dc.date.sdate2010-06-12en_US
dc.date.rdate2010-06-12
dc.date.adate2010-06-12en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record