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dc.contributor.authorFrey, Randall Scotten
dc.date.accessioned2014-03-14T21:41:03Zen
dc.date.available2014-03-14T21:41:03Zen
dc.date.issued1988-02-15en
dc.identifier.otheretd-07212010-020434en
dc.identifier.urihttp://hdl.handle.net/10919/43857en
dc.description.abstractA study was conducted to determine the effects of trenbolone acetate (TBA) and estradiol-17B (E2) implantation on the characteristics of the glucocorticoid and E2 receptor, skeletal muscle protein turnover and tissue growth. Twenty-four lambs were utilized. Trenbolone acetate did not ,affect (P>.10) degradation rates in the semitendinosus (ST) and triceps brachii (TB) muscles, the production of cortisol, adrenal weights and cytosolic glucocorticoid binding capacity (Bmax). Trenbolone acetate decreased synthesis rate of muscle protein (P<.Ol), the percent of [3H] dexamethasone binding in the nuclear fraction, Bmax and the disociation constant (Kd) of the cytosolic E2 receptor, only in the TB muscle. Deoxyribonucleic acid (DNA) of the TB was increased (P<.05) with TBA. Pituitary weights were decreased (P<.005) with TBA and increased (P<.Ol) with E2. Estradiol decreased (P<.05) Bmax of the cytosolic E2 receptor in the ST and decreased (P<.05) Bmax of the nuclear E2 receptor in the TB muscle. The TB muscle had greater (P<.05) synthesis rates than the ST and the protein:RNA ratio was decreased (P<.05) in the TB. The TB muscle had greater (P<.005) Bmax for the cytosolic glucocorticoid receptor.en
dc.format.extentxii, 195 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.publisherVirginia Techen
dc.relation.isformatofOCLC# 18138057en
dc.relation.haspartLD5655.V855_1988.F739.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V855 1988.F739en
dc.subject.lcshEstrogen -- Receptorsen
dc.subject.lcshGlucocorticoids -- Receptorsen
dc.subject.lcshLambs -- Growthen
dc.titleCharacterization of estrogen and glucocorticoid receptors, skeletal muscle protein turnover and tissue growth in lambs treated with trenbolone acetate and estradiolen
dc.typeThesisen
dc.contributor.departmentAnimal Scienceen
dc.description.degreeMaster of Scienceen
thesis.degree.nameMaster of Scienceen
thesis.degree.levelmastersen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.disciplineAnimal Scienceen
dc.contributor.committeechairMcCarthy, F. D.en
dc.contributor.committeememberEversole, Dan E.en
dc.contributor.committeememberAkers, Robert Michaelen
dc.contributor.committeememberWebb, Kenneth E. Jr.en
dc.type.dcmitypeTexten
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07212010-020434/en
dc.date.sdate2010-07-21en
dc.date.rdate2010-07-21en
dc.date.adate2010-07-21en


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