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dc.contributor.authorWilliams, Russell Brianen_US
dc.date.accessioned2014-03-14T21:50:03Z
dc.date.available2014-03-14T21:50:03Z
dc.date.issued2002-09-30en_US
dc.identifier.otheretd-11182002-213441en_US
dc.identifier.urihttp://hdl.handle.net/10919/45831
dc.description.abstractThrough a continuing search for anticancer compounds as part of an International Cooperative Biodiversity Grant program, the extracts of two plants were selected for study on the basis of their cytotoxic activity. These extracts were further fractionated to yield four compounds. The structures of these compounds were elucidated with mass spectrometry and 1-D and 2-D NMR spectroscopy. The ethyl acetate extract of the twigs of Garcinia macrophylla from Suriname was weakly cytotoxic in the A2780 human ovarian cancer cell bioassay. The known benzophenone guttiferone A and a new guttiferone analog, named guttiferone G, were isolated from the extract and found to be responsible for the bioactivity. A known triterpene, friedelin, was also isolated from the extract and found to be inactive. The structure of guttiferone A was determined by comparison of its NMR data to those found in the literature. The structure of guttiferone G was determined by comparison to guttiferone A and through careful examination of both 1D and 2D NMR data. An extract of Bridelia tulasneana from Madagascar yielded one compound. It was identified as the known lignan deoxypodophyllotoxin and was responsible for the bioactivity. It was identified by a comparison of its spectral data to those found in the literature and those of an authentic sample.en_US
dc.publisherVirginia Techen_US
dc.relation.haspartChapter1.pdfen_US
dc.relation.haspartVita.pdfen_US
dc.relation.haspartTitle.pdfen_US
dc.relation.haspartChapter3.pdfen_US
dc.relation.haspartChapter2.pdfen_US
dc.relation.haspartTableofContents.pdfen_US
dc.relation.haspartAppendix.pdfen_US
dc.relation.haspartConclusion.pdfen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectPolyprenylated Benzophenoneen_US
dc.subjectGuttiferone Gen_US
dc.subjectGarcinia macrophyllaen_US
dc.subjectNatural productsen_US
dc.subjectDeoxypodophyllotoxinen_US
dc.subjectBridelia tulasneanaen_US
dc.subjectGarciniaen_US
dc.subjectBrideliaen_US
dc.titleIsolation and Structure Elucidation of Cytotoxic Natural Products from Suriname and Madagascaren_US
dc.typeThesisen_US
dc.contributor.departmentChemistryen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberTaylor, Larry T.en_US
dc.contributor.committeememberGandour, Richard D.en_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-11182002-213441/en_US
dc.date.sdate2002-11-18en_US
dc.date.rdate2003-11-25
dc.date.adate2002-11-25en_US


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