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dc.contributorVirginia Techen_US
dc.contributor.authorDickerson, B. D.en_US
dc.contributor.authorGeist, B. L.en_US
dc.contributor.authorSpillman, W. B.en_US
dc.contributor.authorRobertson, J. L.en_US
dc.date.accessioned2014-04-04T15:12:12Z
dc.date.available2014-04-04T15:12:12Z
dc.date.issued2007-01-01
dc.identifier.citationBryan D. Dickerson, Brian L. Geist, William B. Spillman, Jr., and John L. Robertson, "Canine cancer screening via ultraviolet absorbance and fluorescence spectroscopy of serum proteins," Appl. Opt. 46, 8080-8088 (2007). doi: 10.1364/ao.46.008080
dc.identifier.issn1559-128X
dc.identifier.urihttp://hdl.handle.net/10919/46878
dc.description.abstractA cost-effective optical cancer screening and monitoring technique was demonstrated in a pilot study of canine serum samples and was patented for commercialization. Compared to conventional blood chemistry analysis methods, more accurate estimations of the concentrations of albumin, globulins, and hemoglobin in serum were obtained by fitting the near UV absorbance and photoluminescence spectra of diluted serum as a linear combination of component reference spectra. Tracking these serum proteins over the course of treatment helped to monitor patient immune response to carcinoma and therapy. For cancer screening, 70% of dogs with clinical presentation of cancer displayed suppressed serum hemoglobin levels (below 20 mg/dL) in combination with atypical serum protein compositions, that is, albumin levels outside of a safe range (from 4 to 8 g/dL) and globulin levels above or below a more normal range (from 1.7 to 3.7 g/dL). Of the dogs that met these criteria, only 20% were given a false positive label by this cancer screening test. (C) 2007 Optical Society of America.
dc.description.sponsorshipVirginia Tech Applied Biosciences Center
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_US
dc.publisherOptical Society of America
dc.subjectClinical-implicationsen_US
dc.subjectBiomarkersen_US
dc.subjectProteomicsen_US
dc.subjectCarcinomaen_US
dc.subjectDiagnosisen_US
dc.subjectBladderen_US
dc.subjectTumorsen_US
dc.subjectHemeen_US
dc.titleCanine Cancer Screening Via Ultraviolet Absorbance And Fluorescence Spectroscopy Of Serum Proteins
dc.typeArticle - Refereed
dc.identifier.urlhttp://www.opticsinfobase.org/ao/abstract.cfm?URI=ao-46-33-8080
dc.date.accessed2014-02-24
dc.title.serialApplied Optics
dc.identifier.doihttps://doi.org/10.1364/ao.46.008080
dc.type.dcmitypeText


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