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dc.contributor.authorSalmanzadeh, Alirezaen
dc.contributor.authorSano, Michael B.en
dc.contributor.authorGallo-Villanueva, R. C.en
dc.contributor.authorRoberts, Paul C.en
dc.contributor.authorSchmelz, Eva M.en
dc.contributor.authorDavalos, Rafael V.en
dc.date.accessioned2014-05-14T13:35:38Zen
dc.date.available2014-05-14T13:35:38Zen
dc.date.issued2013-01-01en
dc.identifier.citationSalmanzadeh, A.; Sano, M. B.; Gallo-Villanueva, R. C.; Roberts, P. C.; Schmelz, E. M.; Davalos, R. V., "Investigating dielectric properties of different stages of syngeneic murine ovarian cancer cells," Biomicrofluidics 7, 011809 (2013); http://dx.doi.org/10.1063/1.4788921en
dc.identifier.issn1932-1058en
dc.identifier.urihttp://hdl.handle.net/10919/47983en
dc.description.abstractIn this study, the electrical properties of four different stages of mouse ovarian surface epithelial (MOSE) cells were investigated using contactless dielectrophoresis (cDEP). This study expands the work from our previous report describing for the first time the crossover frequency and cell specific membrane capacitance of different stages of cancer cells that are derived from the same cell line. The specific membrane capacitance increased as the stage of malignancy advanced from 15.39 +/- 1.54 mF m(-2) for a non-malignant benign stage to 26.42 +/- 1.22 mF m(-2) for the most aggressive stage. These differences could be the result of morphological variations due to changes in the cytoskeleton structure, specifically the decrease of the level of actin filaments in the cytoskeleton structure of the transformed MOSE cells. Studying the electrical properties of MOSE cells provides important information as a first step to develop cancer-treatment techniques which could partially reverse the cytoskeleton disorganization of malignant cells to a morphology more similar to that of benign cells. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4788921] Actual pdf downloaded from NCBI.en
dc.description.sponsorshipNSF EFRI 0938047en
dc.description.sponsorshipVirginia Tech Institute for Critical Technology and Applied Science (ICTAS)en
dc.description.sponsorshipNIH RO1 CA118846en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherAmerican Institute of Physicsen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectBioelectric phenomenaen
dc.subjectBiomedical measurementen
dc.subjectBiomembranesen
dc.subjectBiomemsen
dc.subjectCanceren
dc.subjectCapacitanceen
dc.subjectCellular biophysicsen
dc.subjectElectrophoresisen
dc.subjectMicrofluidicsen
dc.subjectContactless dielectrophoresisen
dc.subjectContinuous separationen
dc.subjectBlooden
dc.subjectElectrorotationen
dc.subjectSpectroscopyen
dc.subjectFrequenciesen
dc.subjectMembranesen
dc.subjectBacteriaen
dc.subjectProgressen
dc.subjectSpectraen
dc.subjectBiophysicsen
dc.subjectNanoscience & nanotechnologyen
dc.subjectPhysics, fluids & plasmasen
dc.titleInvestigating dielectric properties of different stages of syngeneic murine ovarian cancer cellsen
dc.typeArticle - Refereeden
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.contributor.departmentInstitute for Critical Technology and Applied Science (ICTAS)en
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.identifier.urlhttp://scitation.aip.org/content/aip/journal/bmf/7/1/10.1063/1.4788921en
dc.date.accessed2014-05-09en
dc.title.serialBiomicrofluidicsen
dc.identifier.doihttps://doi.org/10.1063/1.4788921en
dc.type.dcmitypeTexten


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