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dc.contributorVirginia Tech
dc.contributor.authorHurton, L.
dc.contributor.authorBerkson, J.
dc.date.accessioned2014-05-14T14:36:48Z
dc.date.available2014-05-14T14:36:48Z
dc.date.issued2006-04
dc.identifier.citationHurton, Lenka and Berkson, Jim (2006). "Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process," Fishery Bulletin, 104(2), pp. 293-298. http://fishbull.noaa.gov/1042/hurton.pdf
dc.identifier.issn0090-0656
dc.identifier.urihttp://hdl.handle.net/10919/48012
dc.description.abstractBiomedical companies catch and bleed horseshoe crabs for the production of Limulus amebocyte lysate (LAL), a product used for protecting public health (Berkson and Shuster, 1999). LAL is a clotting agent, derived solely from horseshoe crab blood cells, which is used to detect the presence of pathogenic gramnegative bacteria in injectable drugs and implantable medical and dental devices (Mikkelsen, 1988; Novitsky, 1991). In addition, LAL is used in many diagnostic tests for such illnesses as gram-negative bacterial meningitis and typhoid fever (Ding and Ho, 2001). Because the LAL test allows one to detect femtogram levels of endotoxin (Ding and Ho, 2001), it is the most effective test for detecting endotoxin contamination, and its increasing use in medical and pharmaceutical laboratories makes it a highly valued product.
dc.description.sponsorshipNOAA Office of Sea Grant, US Dept of Commerce, Grant no. NA96RG0025
dc.language.isoen_US
dc.publisherNational Marine Fisheries Service Scientific Publication Office
dc.subjectdelaware bay
dc.subjectblood
dc.subjectfisheries
dc.titlePotential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process
dc.typeArticle
dc.identifier.urlhttp://fishbull.noaa.gov/1042/hurton.pdf
dc.date.accessed2014-05-12
dc.title.serialFishery Bulletin


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