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dc.contributorVirginia Techen_US
dc.contributor.authorMarathe, Achlaen_US
dc.contributor.authorLewis, Bryanen_US
dc.contributor.authorBarrett, Christopher L.en_US
dc.contributor.authorChen, Jiangzhuoen_US
dc.contributor.authorMarathe, Madhaven_US
dc.contributor.authorEubank, Stephenen_US
dc.contributor.authorMa, Yifeien_US
dc.date.accessioned2014-06-17T20:12:06Z
dc.date.available2014-06-17T20:12:06Z
dc.date.issued2011-09-22en_US
dc.identifier.citationMarathe A, Lewis B, Barrett C, Chen J, Marathe M, et al. (2011) Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza. PLoS ONE 6(9): e25149.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10919/48986
dc.description.abstractThis research compares the performance of bottom-up, self-motivated behavioral interventions with top-down interventions targeted at controlling an “Influenza-like-illness”. Both types of interventions use a variant of the ring strategy. In the first case, when the fraction of a person's direct contacts who are diagnosed exceeds a threshold, that person decides to seek prophylaxis, e.g. vaccine or antivirals; in the second case, we consider two intervention protocols, denoted Block and School: when a fraction of people who are diagnosed in a Census Block (resp., School) exceeds the threshold, prophylax the entire Block (resp., School). Results show that the bottom-up strategy outperforms the top-down strategies under our parameter settings. Even in situations where the Block strategy reduces the overall attack rate well, it incurs a much higher cost. These findings lend credence to the notion that if people used antivirals effectively, making them available quickly on demand to private citizens could be a very effective way to control an outbreak.en_US
dc.description.sponsorshipNational Science Foundationen_US
dc.description.sponsorshipDivision of Computer and Network Systemsen_US
dc.description.sponsorshipDivision of Social and Economic Sciencesen_US
dc.description.sponsorshipOffice of Cyberinfrastructureen_US
dc.description.sponsorshipDefense Threat Reduction Agencyen_US
dc.description.sponsorshipNaval Surface Warfare Center Dahlgren Divisionen_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen_US
dc.description.sponsorshipCNS-0626964en_US
dc.description.sponsorshipSES-0729441en_US
dc.description.sponsorshipOCI-0904844en_US
dc.description.sponsorshipCNS-0831633en_US
dc.description.sponsorshipCNS-0845700en_US
dc.description.sponsorshipCNS-1011769en_US
dc.description.sponsorshipOCI-1032677en_US
dc.description.sponsorshipHDTRA1-0901-0017en_US
dc.description.sponsorshipHDTRA1-07-C-0113en_US
dc.description.sponsorshipDE-SC0003957en_US
dc.description.sponsorshipN00178-09-D-3017 DEL ORDER 13en_US
dc.description.sponsorship2U01GM070694-7en_US
dc.description.sponsorshipHHSN272201000056Cen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectAntiviral therapeuticsen_US
dc.subjectDiagnostic medicineen_US
dc.subjectProphylaxisen_US
dc.subjectPublic and occupational healthen_US
dc.subjectPublic policyen_US
dc.subjectSchoolsen_US
dc.subjectSocial networksen_US
dc.subjectVaccinesen_US
dc.titleComparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenzaen_US
dc.typeArticle - Refereeden_US
dc.identifier.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025149en_US
dc.date.accessed2014-05-05en_US
dc.title.serialPLoS ONEen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0025149


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