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dc.contributorVirginia Tech
dc.contributor.authorWitonsky, Sharon G.
dc.contributor.authorGogal, Robert M.
dc.contributor.authorDuncan, Robert B.
dc.contributor.authorLindsay, David S.
dc.date.accessioned2014-06-20T14:13:21Z
dc.date.available2014-06-20T14:13:21Z
dc.date.issued2003-10
dc.identifier.citationSharon G. Witonsky, Robert M. Gogal Jr., Robert B. Duncan, and David S. Lindsay (2003). "Protective immune response to experimental infection with Sarcocystis neurona in C57BL/6 mice," Journal of Parasitology: October 2003, Vol. 89, No. 5, pp. 924-931. doi: http://dx.doi.org/10.1645/GE-67R
dc.identifier.issn0022-3395
dc.identifier.urihttp://hdl.handle.net/10919/49079
dc.description.abstractImmunocompetent C57BL/6 mice were infected with Sarcocystis neurona merozoites to assess the protective immune response to active infection. Using a direct agglutination test, all infected mice seroconverted to S. neurona merozoite antigens by day 14 postinfection (PI). Further, mice developed splenomegaly and bilateral symmetrical lymphadenopathy by day 14 PI, which appeared to be resolving by day 28 PI. Histologic analysis revealed a marked increase in germinal center formation in the spleen and lymph nodes by day 14 PI. Corresponding to gross and histopathological changes, the percentage of B-cells decreased significantly by day 14 PI but then increased significantly and persisted at day 28 PI in the blood, spleen, and multiple lymph nodes. There was a sharp nonspecific significant decrease in CD4 percentages by day 14 PI in the blood, spleen, and lymph nodes. Early-activation CD8 lymphocytes (CD62/CD8) were significantly down-regulated coinciding with a significant compensatory up-regulation of memory (CD44/CD8) lymphocytes in multiple organs. We propose that the protective cell-mediated immune response to S. neurona involves both CD4 and CD8 cells, with CD8 lymphocytes appearing to play a more critical role.
dc.description.sponsorshipCSREES Animal Health and Disease
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_US
dc.publisherAmerican Society of Parasitology
dc.subjectequine protozoal myeloencephalitis
dc.subjectnitric-oxide
dc.subjecttoxoplasma-gondii
dc.subjectvirus
dc.subjectmemory
dc.subjectencephalomyelitis
dc.subjectexpression
dc.subjectcells
dc.subjectparasitology
dc.titleProtective immune response to experimental infection with Sarcocystis neurona in C57BL/6 mice
dc.typeArticle - Refereed
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-67R
dc.date.accessed2014-06-16
dc.title.serialJournal of Parasitology
dc.identifier.doihttps://doi.org/10.1645/ge-67r
dc.type.dcmitypeText


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