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dc.contributor.authorLau, Eric HYen_US
dc.contributor.authorZheng, Jiandongen_US
dc.contributor.authorTsang, Tim Ken_US
dc.contributor.authorLiao, Qiaohongen_US
dc.contributor.authorLewis, Bryanen_US
dc.contributor.authorBrownstein, John Sen_US
dc.contributor.authorSanders, Sharonen_US
dc.contributor.authorWong, Jessica Yen_US
dc.contributor.authorMekaru, Sumiko Ren_US
dc.contributor.authorRivers, Caitlinen_US
dc.contributor.authorWu, Pengen_US
dc.contributor.authorJiang, Huien_US
dc.contributor.authorLi, Yuen_US
dc.contributor.authorYu, Jianxingen_US
dc.contributor.authorZhang, Qianen_US
dc.contributor.authorChang, Zhaoruien_US
dc.contributor.authorLiu, Fengfengen_US
dc.contributor.authorPeng, Zhibinen_US
dc.contributor.authorLeung, Gabriel Men_US
dc.contributor.authorFeng, Luzhaoen_US
dc.contributor.authorCowling, Benjamin Jen_US
dc.contributor.authorYu, Hongjieen_US
dc.date.accessioned2014-06-23T15:14:37Z
dc.date.available2014-06-23T15:14:37Z
dc.date.issued2014-05-28
dc.identifier.citationBMC Medicine. 2014 May 28;12(1):88en_US
dc.identifier.urihttp://hdl.handle.net/10919/49098
dc.description.abstractBackground Appropriate public health responses to infectious disease threats should be based on best-available evidence, which requires timely reliable data for appropriate analysis. During the early stages of epidemics, analysis of ‘line lists’ with detailed information on laboratory-confirmed cases can provide important insights into the epidemiology of a specific disease. The objective of the present study was to investigate the extent to which reliable epidemiologic inferences could be made from publicly-available epidemiologic data of human infection with influenza A(H7N9) virus. Methods We collated and compared six different line lists of laboratory-confirmed human cases of influenza A(H7N9) virus infection in the 2013 outbreak in China, including the official line list constructed by the Chinese Center for Disease Control and Prevention plus five other line lists by HealthMap, Virginia Tech, Bloomberg News, the University of Hong Kong and FluTrackers, based on publicly-available information. We characterized clinical severity and transmissibility of the outbreak, using line lists available at specific dates to estimate epidemiologic parameters, to replicate real-time inferences on the hospitalization fatality risk, and the impact of live poultry market closure. Results Demographic information was mostly complete (less than 10% missing for all variables) in different line lists, but there were more missing data on dates of hospitalization, discharge and health status (more than 10% missing for each variable). The estimated onset to hospitalization distributions were similar (median ranged from 4.6 to 5.6 days) for all line lists. Hospital fatality risk was consistently around 20% in the early phase of the epidemic for all line lists and approached the final estimate of 35% afterwards for the official line list only. Most of the line lists estimated >90% reduction in incidence rates after live poultry market closures in Shanghai, Nanjing and Hangzhou. Conclusions We demonstrated that analysis of publicly-available data on H7N9 permitted reliable assessment of transmissibility and geographical dispersion, while assessment of clinical severity was less straightforward. Our results highlight the potential value in constructing a minimum dataset with standardized format and definition, and regular updates of patient status. Such an approach could be particularly useful for diseases that spread across multiple countries.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleAccuracy of epidemiological inferences based on publicly available information: retrospective comparative analysis of line lists of human cases infected with influenza A(H7N9) in Chinaen_US
dc.typeArticle - Refereed
dc.date.updated2014-06-23T15:14:37Z
dc.description.versionPeer Reviewed
dc.rights.holderEric HY Lau et al.; licensee BioMed Central Ltd.en_US
dc.title.serialBMC Medicine
dc.identifier.doihttps://doi.org/10.1186/1741-7015-12-88
dc.type.dcmitypeText


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International