Now showing items 1-7 of 7
Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells
(Nature Publishing Group, 2014-06-01)
Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB. Yaa Mice
IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immunoglobulins. IL6 also cooperates with IL21 to promote differentiation of CD4+ T follicular helper cells (TFH). Elevated ...
Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency
(Nature Publishing Group, 2016-04-27)
Application of genetically engineered (GE) large animals carrying multi-allelic modifications has been hampered by low efficiency in production and extended gestation period compared to rodents. Here, we rapidly generated ...
Investigation of the Chromosome Regions with Significant Affinity for the Nuclear Envelope in Fruit Fly - A Model Based Approach
Three dimensional nuclear architecture is important for genome function, but is still poorly understood. In particular, little is known about the role of the ‘‘boundary conditions’’ – points of attachment between chromosomes ...
Bursts of Bipolar Microsecond Pulses Inhibit Tumor Growth
(Nature Publishing Group, 2015-10-13)
Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, ...
A Numerical Investigation of the Electric and Thermal Cell Kill Distributions in Electroporation-Based Therapies in Tissue
Electroporation-based therapies are powerful biotechnological tools for enhancing the delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs). Electrochemotherapy (ECT) and gene therapy based on ...