Now showing items 1-10 of 22
Mammalian Brain Development is Accompanied by a Dramatic Increase in Bipolar DNA Methylation
(Nature Publishing Group, 2016-09-02)
A Hidden Transhydrogen Activity of a FMN-Bound Diaphorase under Anaerobic Conditions
Background Redox cofactors of NADH/NADPH participate in many cellular metabolic pathways for facilitating the electron transfer from one molecule to another in redox reactions. Transhydrogenase plays an important role in ...
A Bayesian Assignment Method for Ambiguous Bisulfite Short Reads
DNA methylation is an epigenetic modification critical for normal development and diseases. The determination of genome-wide DNA methylation at single-nucleotide resolution is made possible by sequencing bisulfite treated ...
A Rapid Method for Refolding Cell Surface Receptors and Ligands
(Nature Publishing Group, 2016-05-24)
Effects of Cytokinin and Nitrogen on Drought Tolerance of Creeping Bentgrass
Genome-Wide Assessment of Efficiency and Specificity in CRISPR/Cas9 Mediated Multiple Site Targeting in Arabidopsis
Simultaneous multiplex mutation of large gene families using Cas9 has the potential to revolutionize agriculture and plant sciences. The targeting of multiple genomic sites at once raises concerns about the efficiency and ...
GPR30 regulates diet-induced adiposity in female mice and adipogenesis in vitro
(Nature Publishing Group, 2016-10-04)
Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB. Yaa Mice
IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immunoglobulins. IL6 also cooperates with IL21 to promote differentiation of CD4+ T follicular helper cells (TFH). Elevated ...
Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency
(Nature Publishing Group, 2016-04-27)
Application of genetically engineered (GE) large animals carrying multi-allelic modifications has been hampered by low efficiency in production and extended gestation period compared to rodents. Here, we rapidly generated ...