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dc.contributor.authorReese, Laura Michelleen_US
dc.date.accessioned2015-02-19T09:00:21Z
dc.date.available2015-02-19T09:00:21Z
dc.date.issued2015-01-05en_US
dc.identifier.othervt_gsexam:4049en_US
dc.identifier.urihttp://hdl.handle.net/10919/51539
dc.description.abstractEmerging technologies in the healthcare industry encompass revolutionary devices or drugs that have the potential to change how healthcare will be practiced in the future. While there are several emerging healthcare technologies in the pipeline, a few key innovations are slated to be implemented clinically sooner based on their mass appeal and potential for healthcare breakthroughs. This thesis will focus on specific topics in the emerging technological fields of nanotechnology for photothermal cancer therapy, 3D printing for irreversible electroporation applications, and imageable biomaterials. While these general areas are receiving significant attention, we highlight the potential opportunities and limitations presented by our select efforts in these fields. First, in the realm of nanomedicine, we discuss the optimization and characterization of sodium thiosulfate facilitated gold nanoparticle synthesis. While many nanoparticles have been examined as agents for photothermal cancer therapy, we closely examine the structure and composition of these specific nanomaterials and discuss key findings that not only impact their future clinical use, but elucidate the importance of characterization prior to preclinical testing. Next, we examine the potential use of 3D printing to generate unprecedented multimodal medical devices for local pancreatic cancer therapy. This additive manufacturing technique offers exquisite design detail control, facilitating tools that would otherwise be difficult to fabricate by any other means. Lastly, in the field of imageable biomaterials, we demonstrate the development of composite catheters that can be visualized with near infrared imaging. This new biomaterial allows visualization with near infrared imaging, offering potentially new medical device opportunities that alleviate the use of ionizing radiation. This collective work emphasizes the need to thoroughly optimize and characterize emerging technologies prior to preclinical testing in order to facilitate rapid translation.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectIrreversible Electroporationen_US
dc.subjectAdditive Manufacturingen_US
dc.subjectNear Infrared Imagingen_US
dc.subjectGold Nanoparticlesen_US
dc.titleOptimizing Emerging Healthcare Innovations in 3D Printing, Nanomedicine, and Imageable Biomaterialsen_US
dc.typeThesisen_US
dc.contributor.departmentBiomedical Engineeringen_US
dc.description.degreeMSen_US
thesis.degree.nameMSen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiomedical Engineeringen_US
dc.contributor.committeechairBickford, Lissett Ren_US
dc.contributor.committeememberLee, Yong Wooen_US
dc.contributor.committeememberWhittington, Abby Rebeccaen_US


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