Branched Peptide Boronic Acids (BPBAs): A Novel Mode of Binding Towards RNA

Abstract

We report branched peptideboronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.