Branched Peptide Boronic Acids (BPBAs): A Novel Mode of Binding Towards RNA

Date
2013-02-07Author
Zhang, Wenyu
Bryson, David I.
Crumpton, Jason B.
Wynn, Jessica E.
Santos, Webster L.
Metadata
Show full item recordAbstract
We report branched peptideboronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.