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dc.contributorVirginia Tech. Department of Chemistry
dc.contributorVirginia Tech. Center for Drug Discovery
dc.contributorCalifornia State University, Fresno. Department of Chemistry
dc.contributor.authorChen, Qiao-Hong
dc.contributor.authorKingston, David G. I.
dc.identifier.citationChen, Q.-H., & Kingston, D. G. I. (2014). Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads. Natural Product Reports, 31(9), 1202-1226. doi: 10.1039/C4NP00024B
dc.description.abstractZampanolide is a marine natural macrolide and a recent addition to the family of microtubule-stabilizing cytotoxic agents. Zampanolide exhibits unique effects on tubulin assembly and is more potent than paclitaxel against several multi-drug resistant cancer cell lines. A high-resolution crystal structure of xB-tubulin in complex with zampanolide explains how taxane-site microtubule-stabilizing agents promote microtubule assemble and stability. This review provides an overview of current developments of zampanolide and its related but less potent analogue dactylolide, covering their natural sources and isolation, structure and conformation, cytotoxic potential, structure_activity studies, mechanism of action, and syntheses.
dc.description.sponsorshipCalifornia State University (CSU) Fresno
dc.description.sponsorshipCalifornia State University (CSU) Fresno. National Institutes of Health RIMI Program - P20MD002732
dc.publisherThe Royal Society of Chemistry
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unported
dc.subjectCytotoxic agents
dc.subjectMicrotubule stabilizing agents
dc.subjectMulti-drug resistance
dc.subjectAnti-cancer drugs
dc.titleZampanolide and Dactylolide: Cytotoxic Tubulin-Assembly Agents and Promising Anticancer Leads
dc.typeArticle - Refereed
dc.title.serialNatural Product Reports

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Creative Commons Attribution-NonCommercial 3.0 Unported
License: Creative Commons Attribution-NonCommercial 3.0 Unported