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dc.contributorVirginia Tech. Charles E. Via, Jr. Department of Civil and Environmental Engineeringen_US
dc.contributor.authorVejerano, Eric P.en_US
dc.contributor.authorMa, Yanjunen_US
dc.contributor.authorHolder, Amara L.en_US
dc.contributor.authorPruden, Amyen_US
dc.contributor.authorElankumaran, Subbiahen_US
dc.contributor.authorMarr, Linsey C.en_US
dc.identifier.citationVejerano, E. P., Ma, Y., Holder, A. L., Pruden, A., Elankumaran, S., & Marr, L. C. (2015). Toxicity of particulate matter from incineration of nanowaste. Environmental Science: Nano, 2(2), 143-154. doi: 10.1039/C4EN00182F
dc.description.abstractDisposal of some nanomaterial-containing waste by incineration and the subsequent formation of particulate matter (PM) along with hazardous combustion by-products are inevitable. The effect of nanomaterials on the toxicity of the PM is unknown. We assessed the oxidative potential (OP) and toxicity of PM resulting from the incineration of pure nanomaterials and of paper and plastic wastes containing Ag, NiO, TiO2, ceria, C60, Fe2O3, or CdSe/ZnS quantum dots (CdSe QD) at mass loadings ranging from 0.1 wt% to 10 wt%. We measured reactive oxygen species (ROS) using the dichlorofluorescein assay, and we also measured consumption of ascorbic acid, dithiothreitol (DTT), glutathione (GSH), or uric acid antioxidants from raw and solvent-extracted PM, denoted “cleaned PM”. We determined cytotoxicity and genotoxicity of PM to A549 human lung epithelial cells with the WST-1 cell viability and histone immunofluorescence assays, respectively. In most cases, the presence of nanomaterials in the waste did not significantly affect the OP of PM; however, PM derived from waste containing Ag, TiO2, and C60 had elevated ROS response in the GSH and DTT assays. The ratio of reduced to oxidized glutathione was significantly higher for cleaned PM compared to raw PM for almost all nanomaterials at almost all concentrations, indicating that combustion by-products adsorbed on raw PM play an important role in determining OP. The presence of nanomaterials did not significantly modify the cytotoxicity or genotoxicity of the PM. Different antioxidants used to assess OP had varying sensitivity towards organic compounds v. metals in PM. The presence of these seven nanomaterials at low concentrations in the waste stream is not expected to exacerbate the hazard posed by PM that is produced by incineration.
dc.publisherThe Royal Society of Chemistry
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unported
dc.subjectNanowaste incinerationen_US
dc.subjectOxidative potentialen_US
dc.titleToxicity of Particulate Matter from Incineration of Nanowasteen_US
dc.typeArticle - Refereeden_US
dc.description.notesSupplementary information is included in a separate file
dc.description.notes2015 Royal Society of Chemistry Open Access Gold Articleen_US
dc.title.serialEnvironmental Science: Nano

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