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dc.contributor.authorKibria, Mohammad Gen_US
dc.contributor.authorElahi, Rubayeten_US
dc.contributor.authorMohon, Abu Nen_US
dc.contributor.authorKhan, Wasif Aen_US
dc.contributor.authorHaque, Rashidulen_US
dc.contributor.authorAlam, Mohammad Sen_US
dc.identifier.citationMalaria Journal. 2015 Jul 11;14(1):267en_US
dc.description.abstractBackground Plasmodium vivax is the second most prevalent human malaria parasite in Bangladesh; however, there are no data of its genetic diversity. Several molecular markers are available where Pvcsp, Pvmsp 1 and Pvmsp 3α are most commonly used for P. vivax genotyping studies. The aim of the study was to investigate the population structure of P. vivax in Bangladesh. Methods A total of 102 P. vivax-positive blood samples were collected from different malaria-endemic areas in Bangladesh and subsequently analysed for those three genotyping markers. Nested PCR was performed for diagnosis and genotyping analysis followed by PCR–RFLP to detect genetic diversity using Pvcsp, Pvmsp 1 and Pvmsp 3α markers. Results Analysis of Pvcsp showed that the VK210 repeat type was highly prevalent (64.7%, 66/102) compared to VK247 (35.3%, 36/102), although the prevalence of VK247 was higher than other Southeast Asian countries. Analysis of these three genes revealed a diverse, circulating population of P. vivax where a total of ten, 56 and 35 distinct genotypes were detected for Pvcsp, Pvmsp 1 and Pvmsp 3α, respectively. Conclusion This genotyping observation of P. vivax is the first report from Bangladesh and will provide valuable information for establishing the genotyping methods and circulating genetic variants of these three markers available in Bangladesh.en_US
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.titleGenetic diversity of Plasmodium vivax in clinical isolates from Bangladeshen_US
dc.typeArticle - Refereed
dc.description.versionPeer Reviewed
dc.rights.holderKibria et al.en
dc.title.serialMalaria Journal

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Creative Commons Attribution 4.0 International
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