Now showing items 1211-1220 of 1315
MIXFIT: A microcomputer-based routine for fitting heterogeneous probability distribution functions to data
(American Society of Agricultural and Biological Engineers, 1994)
Some engineering data represent a mixture of data from two distinct populations or result from two or more concomitant phenomena. Homogeneous probability density functions are not always suitable for representing such data. ...
Technical Note: Improved nutrient parameters for modeling diffuse pollution in the tropics
(American Society of Agricultural and Biological Engineers, 2009)
Nonpoint-source (NPS) or diffuse pollution is a major environmental problem in developed countries, and modeling is an important tool used to evaluate the effectiveness of pollution control measures. The use of NPS models ...
Risk management in the development of new products in the pharmaceutical industry
(Academic Journals, 2008-10-31)
One of the greatest challenges facing the pharmaceutical industry is the process of selecting which new products to develop. In this study, the product development and investment decision problem was examined. A hypothetical ...
Reliability of odor offensiveness quantification using the refined cloth swatch olfactometric technique
(American Society of Agricultural and Biological Engineers, 2001)
The cloth swatch olfactometric technique uses flannel swatches to absorb odors for presentation to a trained human sensory panel. This study examined the reliability of the refined cloth swatch technique used to facilitate ...
Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States.
(American Society for Microbiology, 2018-04-04)
Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy.
While gene-directed enzyme prodrug therapy has shown potential as a cancer therapeutic in animal and clinical trials, concerns over the efficacy, selectivity, and safety of gene delivery vehicles have restricted its advance. ...
Phytoestrogen Genistein Up-Regulates Endothelial Nitric Oxide Synthase Expression Via Activation of cAMP Response Element-Binding Protein in Human Aortic Endothelial Cells
(Endocrine Society, 2012-07)
We previously reported that genistein, a phytoestrogen, up-regulates endothelial nitric oxide synthase (eNOS) and prevents hypertension in rats that are independent of estrogen signaling machinery. However, how genistein ...
Insights into the Evolution and Function of Auxin Signaling F-Box Proteins in Arabidopsis thaliana Through Synthetic Analysis of Natural Variants.
The evolution of complex body plans in land plants has been paralleled by gene duplication and divergence within nuclear auxin-signaling networks. A deep mechanistic understanding of auxin signaling proteins therefore may ...
Growth Hormone Stimulates Transcription of the Fibroblast Growth Factor 21 Gene in the Liver through the Signal Transducer and Activator of Transcription 5
(Endocrine Society, 2012-02)
Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator. Interestingly, FGF21 is also known to inhibit Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) signaling ...
A protein therapeutic modality founded on molecular regulation.
The exquisite specificity of proteins is a key feature driving their application to anticancer therapies. The therapeutic potential of another fundamental property of proteins, their ability to be regulated by molecular ...