Now showing items 1-10 of 1408
Proteogenomic Analysis of Protein Sequence Alterations in Breast Cancer Cells
(Nature Research, 2019-07-18)
Cancer evolves as a result of an accumulation of mutations and chromosomal aberrations. Developments in sequencing technologies have enabled the discovery and cataloguing of millions of such mutations. The identification ...
Recurrent chimeric fusion RNAs in non-cancer tissues and cells
Gene fusions and their products (RNA and protein) were once thought to be unique features to cancer. However, chimeric RNAs can also be found in normal cells. Here, we performed, curated and analyzed nearly 300 RNA-Seq ...
Microfluidic reactors for advancing the MS analysis of fast biological responses
(Nature Publishing Group, 2019-02-11)
The response of cells to physical or chemical stimuli is complex, unfolding on time-scales from seconds to days, with or without de novo protein synthesis, and involving signaling processes that are transient or sustained. ...
Microfluidic LC Device with Orthogonal Sample Extraction for On-Chip MALDI-MS Detection
(The Royal Society of Chemistry, 2013-03-20)
A microfluidic device that enables on-chip matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS) detection for liquid chromatography (LC) separations is described. The device comprises an array of ...
Cell Cycle Model System for Advancing Cancer Biomarker Research
(Springer Nature, 2017-12-21)
Progress in understanding the complexity of a devastating disease such as cancer has underscored the need for developing comprehensive panels of molecular markers for early disease detection and precision medicine applications. ...
Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1
(Springer Nature, 2019-07-26)
Tom1 transports endosomal ubiquitinated proteins that are targeted for degradation in the lysosomal pathway. Infection of eukaryotic cells by Shigella flexneri boosts oxygen consumption and promotes the synthesis of ...
Insulin stimulated MCF7 breast cancer cells: Proteome dataset
The proteome data provided in this article were acquired from MCF7 breast cancer cells stimulated with insulin, and were generated by using a 2D-SCX (strong cation exchange)/RPLC (reversed phase liquid chromatography) ...
Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle
(BioMed Central, 2014)
Background: Cancer cells are characterized by a deregulated cell cycle that facilitates abnormal proliferation by allowing cells to by-pass tightly regulated molecular checkpoints such as the G1/S restriction point. To ...
Data-driven structured realization
(Elsevier Science Inc, 2018-01-15)
Experimental logging alters the abundance and community composition of ovipositing mosquitoes in the southern Appalachians
1. The loss of intact forest via logging can influence vector-borne disease dynamics in part by altering the abundance or diversity of mosquito species. Using an experimental field approach, we characterised how two types ...