Now showing items 21-30 of 56
Cell-free protein synthesis of norovirus virus-like particles
(Royal Society of Chemistry, 2017-05-25)
Norovirus vaccine development largely depends on recombinant virus-like-particles (VLPs). Norovirus VLPs have been produced in several cell-based expression systems with long production times. Here we report, for the first ...
A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of Brucella abortus Mediates Host-Pathogen Interactions
(American Society for Microbiology, 2017-05)
In Brucella abortus, two small RNAs (sRNAs), AbcR1 and AbcR2, are responsible for regulating transcripts encoding ABC-type transport systems. AbcR1 and AbcR2 are required for Brucella virulence, as a double chromosomal ...
Capsular Polysaccharide Interferes with Biofilm Formation by Pasteurella multocida Serogroup A
(American Society for Microbiology, 2017-11)
Pasteurella multocida is an important multihost animal and zoonotic pathogen that is capable of causing respiratory and multisystemic diseases, bacteremia, and bite wound infections. The glycosaminoglycan capsule of P. ...
Multi-scale immunoepidemiological modeling of within-host and between-host HIV dynamics: systematic review of mathematical models
Objective The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the ...
Leaky Gut As a Danger Signal for Autoimmune Diseases
(Frontiers Media Sa, 2017-05-23)
Glycosylation of a Capsule-Like Complex (CLC) by Francisella novicida Is Required for Virulence and Partial Protective Immunity in Mice
Francisella tularensis is a Gram-negative bacterium and the etiologic agent of tularemia. F. tularensis may appear encapsulated when examined by transmission electron microscopy (TEM), which is due to production of an ...
Rice Bran and Probiotics Alter the Porcine Large Intestine and Serum Metabolomes for Protection against Human Rotavirus Diarrhea
Human rotavirus (HRV) is a leading cause of severe childhood diarrhea, and there is limited vaccine efficacy in the developing world. Neonatal gnotobiotic pigs consuming a prophylactic synbiotic combination of probiotics ...
A case of stiff dog syndrome associated with anti-glutamic acid decarboxylase antibodies
Abstract Background The stiff person syndrome (SPS) is a rare and debilitating autoimmune disorder with an unknown pathogenesis and variable clinical presentation that can ...
Antibiotics ameliorate lupus-like symptoms in mice
Gut microbiota and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of systemic lupus erythematosus (SLE) is unclear. Here we report that oral antibiotics ...
Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates
(Springer Nature, 2017-11-17)
Determining the mechanisms by which a species adapts to its environment is a key endeavor in the study of evolution. In particular, relatively little is known about how transcriptional processes are fine-tuned to adjust ...