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dc.contributor.authorLanglois, Daniel K.en_US
dc.contributor.authorSutton, Deanna A.en_US
dc.contributor.authorSwenson, Cheryl L.en_US
dc.contributor.authorBailey, Chris J.en_US
dc.contributor.authorWiederhold, Nathan P.en_US
dc.contributor.authorNelson, Nathan C.en_US
dc.contributor.authorThompson, Elizabeth H.en_US
dc.contributor.authorWickes, Brian L.en_US
dc.contributor.authorFrench, Stephanieen_US
dc.contributor.authorFu, Jianminen_US
dc.contributor.authorVilar-Saavedra, Pauloen_US
dc.contributor.authorPeterson, Stephen W.en_US
dc.contributor.editorWarnock, D. W.en_US
dc.date.accessioned2015-11-29T04:13:28Z
dc.date.available2015-11-29T04:13:28Z
dc.date.issued2014-04-17en_US
dc.identifier.citationLanglois, Daniel K. et al. (2014). Clinical, Morphological, and Molecular Characterization of Penicillium canis sp nov., Isolated from a Dog with Osteomyelitis. Journal of Clinical Microbiology, 52(7), 2447-2453. doi:10.1128/jcm.03602-13en_US
dc.identifier.issn0095-1137en_US
dc.identifier.urihttp://hdl.handle.net/10919/64227
dc.description.abstractInfections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid- complexed amphotericin B initially, followed by long-term combination therapy with terbinafine and ketoconazole. A detailed morphological and molecular characterization of the mold was undertaken. Sequence analysis of the internal transcribed spacer revealed the isolate to be closely related to Penicillium menonorum and Penicillium pimiteouiense. Additional sequence analysis of beta-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a novel species; the name Penicillium canis sp. nov. is proposed. Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on all media, and a failure to form ascomata distinguish this species from closely related Penicillium species.en_US
dc.description.sponsorshipMichigan State University. College of Veterinary Medicine Trinket Funden_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.rightsIn Copyright (InC)en_US
dc.rightsThis Item is protected by copyright and/or related rights. Some uses of this Item may be deemed fair and permitted by law even without permission from the rights holder(s). For other uses you need to obtain permission from the rights holder(s).en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.titleClinical, Morphological, and Molecular Characterization of Penicillium canis sp nov., Isolated from a Dog with Osteomyelitis
dc.typeArticle - Refereed
dc.typeDataset
dc.rights.holderAmerican Society for Microbiologyen_US
dc.contributor.departmentVirginia-Maryland Regional College of Veterinary Medicine. Department of Small Animal Clinical Sciencesen_US
dc.identifier.urlhttp://jcm.asm.org/content/52/7/2447en_US
dc.date.accessed2015-11-28en_US
dc.title.serialJournal of Clinical Microbiologyen_US
dc.identifier.doihttps://doi.org/10.1128/jcm.03602-13
dc.type.dcmitypeText
dc.type.dcmitypeDataset


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