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dc.contributor.authorLévesque, C. A.en_US
dc.contributor.authorBrouwer, Henken_US
dc.contributor.authorCano, Lilianaen_US
dc.contributor.authorHamilton, John P.en_US
dc.contributor.authorHolt, Carsonen_US
dc.contributor.authorHuitema, Edgaren_US
dc.contributor.authorRaffaele, Sylvainen_US
dc.contributor.authorRobideau, Gregg P.en_US
dc.contributor.authorThines, Marcoen_US
dc.contributor.authorWin, Joeen_US
dc.contributor.authorZerillo, Marcelo M.en_US
dc.contributor.authorBeakes, Gordon W.en_US
dc.contributor.authorBoore, Jeffrey L.en_US
dc.contributor.authorBusam, Danaen_US
dc.contributor.authorDumas, Bernarden_US
dc.contributor.authorFerriera, Steveen_US
dc.contributor.authorFuerstenberg, Susan I.en_US
dc.contributor.authorGachon, Claire M.en_US
dc.contributor.authorGaulin, Elodieen_US
dc.contributor.authorGovers, Francineen_US
dc.contributor.authorGrenville-Briggs, Lauraen_US
dc.contributor.authorHorner, Neilen_US
dc.contributor.authorHostetler, Jessicaen_US
dc.contributor.authorJiang, Rays H.en_US
dc.contributor.authorJohnson, Justinen_US
dc.contributor.authorKrajaejun, Theerapongen_US
dc.contributor.authorLin, Hainingen_US
dc.contributor.authorMeijer, Harold J.en_US
dc.contributor.authorMoore, Barryen_US
dc.contributor.authorMorris, Paulen_US
dc.contributor.authorPhuntmart, Vipapornen_US
dc.contributor.authorPuiu, Danielaen_US
dc.contributor.authorShetty, Jyotien_US
dc.contributor.authorStajich, Jason E.en_US
dc.contributor.authorTripathy, Suchetaen_US
dc.contributor.authorWawra, Stephanen_US
dc.contributor.authorvan West, Pieteren_US
dc.contributor.authorWhitty, Brett R.en_US
dc.contributor.authorCoutinho, Pedro M.en_US
dc.contributor.authorHenrissat, Bernarden_US
dc.contributor.authorMartin, Franken_US
dc.contributor.authorThomas, Paul D.en_US
dc.contributor.authorTyler, Brett Men_US
dc.contributor.authorDe Vries, Ronald P.en_US
dc.contributor.authorKamoun, Sophienen_US
dc.contributor.authorYandell, Marken_US
dc.contributor.authorTisserat, Neden_US
dc.contributor.authorBuell, C. Robinen_US
dc.identifier.citationGenome Biology. 2010 Jul 13;11(7):R73en_US
dc.description.abstractBackground Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species. Results The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions, although, surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host-specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome, including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report of these in a genome outside the metazoans. Conclusions Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.titleGenome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoireen_US
dc.typeArticle - Refereed
dc.description.versionPeer Reviewed
dc.rights.holderLévesque et al.en_US
dc.title.serialGenome Biology

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Creative Commons Attribution 4.0 International
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