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dc.contributorVirginia Tech. Virginia Bioinformatics Instituteen_US
dc.contributorVirginia Tech. Mathematics Departmenten_US
dc.contributorinuTech GmbHen_US
dc.contributor.authorDougherty, Edward T.en_US
dc.contributor.authorTurner, James C.en_US
dc.contributor.authorVogel, Franken_US
dc.contributor.editorMigliore, Micheleen_US
dc.identifier.citationEdward T. Dougherty, James C. Turner, and Frank Vogel, “Multiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarization,” Computational and Mathematical Methods in Medicine, vol. 2014, Article ID 360179, 14 pages, 2014. doi:10.1155/2014/360179en_US
dc.description.abstractTranscranial direct current stimulation (tDCS) continues to demonstrate success as a medical intervention for neurodegenerative diseases, psychological conditions, and traumatic brain injury recovery. One aspect of tDCS still not fully comprehended is the influence of the tDCS electric field on neural functionality. To address this issue, we present a mathematical, multiscale model that couples tDCS administration to neuron electrodynamics. We demonstrate the model’s validity and medical applicability with computational simulations using an idealized two-dimensional domain and then an MRI-derived, three-dimensional human head geometry possessing inhomogeneous and anisotropic tissue conductivities. We exemplify the capabilities of these simulations with real-world tDCS electrode configurations and treatment parameters and compare the model’s predictions to those attained from medical research studies. The model is implemented using efficient numerical strategies and solution techniques to allow the use of fine computational grids needed by the medical community.en_US
dc.description.sponsorshipVirginia Tech. Open Access Subvention Funden_US
dc.format.extent14 p.en_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsAttribution 3.0 Unported*
dc.titleMultiscale Coupling of Transcranial Direct Current Stimulation to Neuron Electrodynamics: Modeling the Influence of the Transcranial Electric Field on Neuronal Depolarizationen_US
dc.typeArticle - Refereeden_US
dc.rights.holderDougherty, Edward T.en_US
dc.rights.holderTurner, James C.en_US
dc.rights.holderVogel, Franen_US
dc.rights.holderCopyright © 2014 Edward T. Dougherty et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.title.serialComputational and Mathematical Methods in Medicineen_US

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