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dc.contributor.authorWynn, Jessica E.en_US
dc.contributor.authorSantos, Webster L.en_US
dc.date.accessioned2016-03-18T22:24:56Z
dc.date.available2016-03-18T22:24:56Z
dc.date.issued2015-04-28en_US
dc.identifier.citationWynn, J. E., & Santos, W. L. (2015). HIV-1 drug discovery: targeting folded RNA structures with branched peptides. Organic & Biomolecular Chemistry, 13(21), 5848-5858. doi:10.1039/C5OB00589Ben_US
dc.identifier.issn1477-0520en_US
dc.identifier.other2015_Wynn_HIV_1_drug_discovery_targeting_fold.pdfen_US
dc.identifier.otherGM093834en_US
dc.identifier.urihttp://hdl.handle.net/10919/64968
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.)en_US
dc.format.extent11 pagesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherThe Royal Society of Chemistryen_US
dc.rightsAttribution-NonCommercial 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/*
dc.titleHIV-1 drug discovery: targeting folded RNA structures with branched peptidesen_US
dc.typeArticle - Refereeden_US
dc.contributor.departmentVirginia Tech. Department of Chemistryen_US
dc.contributor.departmentVirginia Tech Center for Drug Discoveryen_US
dc.description.notes2015 Royal Society of Chemistry Open Access Gold Articleen_US
dc.date.accessed2016-03-17en_US
dc.title.serialOrganic & Biomolecular Chemistryen_US
dc.identifier.doihttps://doi.org/10.1039/C5OB00589Ben_US
dc.identifier.volume13en_US
dc.identifier.issue21en_US
dc.type.dcmitypeTexten_US


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