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dc.contributor.authorWynn, Jessica E.en
dc.contributor.authorSantos, Webster L.en
dc.date.accessioned2016-03-18T22:24:56Zen
dc.date.available2016-03-18T22:24:56Zen
dc.date.issued2015-04-28en
dc.identifier.citationWynn, J. E., & Santos, W. L. (2015). HIV-1 drug discovery: targeting folded RNA structures with branched peptides. Organic & Biomolecular Chemistry, 13(21), 5848-5858. doi:10.1039/C5OB00589Ben
dc.identifier.issn1477-0520en
dc.identifier.other2015_Wynn_HIV_1_drug_discovery_targeting_fold.pdfen
dc.identifier.otherGM093834en
dc.identifier.urihttp://hdl.handle.net/10919/64968en
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy towards this goal is aimed at targeting the native three-dimensional fold of conserved RNA structures. This perspective highlights medium-sized peptides and peptidomimetics used to target two conserved RNA structures of HIV-1. In particular, branched peptides have the capacity to bind in a multivalent fashion, utilizing a large surface area to achieve the necessary affinity and selectivity toward the target RNA.en
dc.description.sponsorshipNational Institutes of Health (U.S.)en
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.)en
dc.format.extent11 pagesen
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.publisherThe Royal Society of Chemistryen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/en
dc.titleHIV-1 drug discovery: targeting folded RNA structures with branched peptidesen
dc.typeArticle - Refereeden
dc.contributor.departmentChemistryen
dc.contributor.departmentCenter for Drug Discoveryen
dc.description.notes2015 Royal Society of Chemistry Open Access Gold Articleen
dc.date.accessed2016-03-17en
dc.title.serialOrganic & Biomolecular Chemistryen
dc.identifier.doihttps://doi.org/10.1039/C5OB00589Ben
dc.identifier.volume13en
dc.identifier.issue21en
dc.type.dcmitypeTexten


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