Now showing items 1-4 of 4

    • Expression of active human factor IX in mammary tissue and of milk non human transgenic mammals 

      The American Red Cross; Virginia Tech Intellectual Properties, Inc.; Drohan, William N.; Velander, William H.; Johnson, John L.; Lubon, Henryk (United States Patent and Trademark Office, 2002-02-05)
      Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals ...
    • Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor 

      Virginia Polytechnic Institute and State University; American National Red Cross; Drohan, William N.; Velander, William H.; Lubon, Henryk (United States Patent and Trademark Office, 2001-07-03)
      A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked ...
    • Transgenic non-human mammals producing fibrinogen in their milk 

      The University of North Carolina at Chapel Hill; The American Red Cross; Virginia Tech Intellectual Properties, Inc.; Drohan, William N.; Velander, William H.; Johnson, John L.; Lubon, Henryk (United States Patent and Trademark Office, 2006-01-10)
      A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a ...
    • Treatment of hemophilia with human Factor IX produced in mammary tissue of transgenic mammals 

      The American Red Cross; Virginia Tech Intellectual Properties, Inc.; Drohan, William N.; Velander, William H.; Lubon, Henryk; Johnson, representative, Mary Ann (United States Patent and Trademark Office, 2008-09-02)
      Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals ...