Chemical modification of shaped hydrogels in non-aqueous medium

Publication Date
1996-06-25Filing Date
1994-08-29Inventor
Glasser, Wolfgang G.
Frazier, Charles E.
Samaranayake, Gamini S.
Metadata
Show full item recordAbstract
A method is described for the chemical modification of pre-shaped hydrogels in non-aqueous medium. The conditions permit the reaction of highly expanded, porous hydrogel particles, such as spherical beads, using pseudo homogeneous reaction conditions in the absence of water. The method involves a three step procedure in which the porous gels are solvent exchanged int a water-free solvent (step 1) with minimal change in gel dimension and porosity; followed by reaction under non-aqueous condition (step 2); and followed by solvent exchange into water (step 3). Many different types of reactions requiring non-aqueous conditions may be carried out using these conditions. The method has particularly been demonstrated for crosslinking fluorinating beads, and for esterifying beads in a reaction involving multifunctional free carboxylic acids in the presence of dicyclohexylcarbodiimide (DCC).
Assignee
Center for Innovative Technology
Virginia Polytechnic Institute and State University
Virginia Tech Intellectual Properties, Inc.
Patent Number
5530111
Application Number
8296171
Primary/U.S. Class
536/56
Other/U.S. Class
536/58
536/84
536/124
CPC Class
C08B3/00
C08B3/14
Patent Type
utility
Collections
- Virginia Tech Patents [545]