Inside-out crosslinked and commercial-scale hydrogels, and sub-macromolecular selective purification using the hyrdogels
Virginia Tech Intellectual Properties, Inc.
Velander, William H.
Van Cott, Kevin E.
Van Tassell, Roger L.
MetadataShow full item record
Relating to chromatographic processes and ion-exchange and affinity matrices, a spatial installation method for a bifunctional reagent that crosslinks and/or activates a polymer matrix is disclosed, with inside-outside installation of a bifunctional reagent on and within a polymer matrix. The polymer matrix is cellulose, agarose, or chitosan particles. The installation may be followed by inside-outside ligand attachment, by further reacting the matrix with a ligand or ionic group so that a higher concentration of ligand or ionic moiety occurs on the intra-particle volume than the outer matrix surface.
- Virginia Tech Patents