Inside-out crosslinked and commercial-scale hydrogels, and sub-macromolecular selective purification using the hyrdogels
Velander, William H.
Van Cott, Kevin E.
Van Tassell, Roger L.
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Relating to chromatographic processes and ion-exchange and affinity matrices, a spatial installation method for a bifunctional reagent that crosslinks and/or activates a polymer matrix is disclosed, with inside-outside installation of a bifunctional reagent on and within a polymer matrix. The polymer matrix is cellulose, agarose, or chitosan particles. The installation may be followed by inside-outside ligand attachment, by further reacting the matrix with a ligand or ionic group so that a higher concentration of ligand or ionic moiety occurs on the intra-particle volume than the outer matrix surface.
Virginia Tech Intellectual Properties, Inc.
- Virginia Tech Patents