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2-debenzoyl-2-acyl taxol derivatives and method for making same
Kingston, David G.
Chaudhary, Ashok Gopal
Gharpure, Milind Moreshwar
Rimoldi, John Matthew
Gunatilaka, A.A. Leslie
MetadataShow full item record
The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: ##STR1## wherein R.sub.1 is an alkyl or substituted alkyl; R.sub.2 is selected from the group consisting of H and C(O)R.sub.a ; R.sub.3 is selected from the group consisting of H, protecting groups, R.sub.b, and C(O)R.sub.b ; R.sub.4 is selected from the group consisting of H and C(O)R.sub.c, and wherein R.sub.a, R.sub.b, and R.sub.c are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that R.sub.a is other than phenyl and 3-hydroxyphenyl.
Virginia Tech Intellectual Properties, Inc.
- Virginia Tech Patents