2-debenzoyl-2-acyl taxol derivatives and method for making same

Publication Date
1999-12-14Filing Date
1997-10-15Inventor
Kingston, David G. I.
Chaudhary, Ashok G.
Gharpure, Milind M.
Rimoldi, John M.
Gunatilaka, A.A. Leslie
Metadata
Show full item recordAbstract
The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: ##STR1## wherein R.sub.1 is an alkyl or substituted alkyl; R.sub.2 is selected from the group consisting of H and C(O)R.sub.a ; R.sub.3 is selected from the group consisting of H, protecting groups, R.sub.b, and C(O)R.sub.b ; R.sub.4 is selected from the group consisting of H and C(O)R.sub.c, and wherein R.sub.a, R.sub.b, and R.sub.c are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that R.sub.a is other than phenyl and 3-hydroxyphenyl.
Assignee
Virginia Tech Intellectual Properties, Inc.
Patent Number
6002023
Application Number
8950590
Primary/U.S. Class
549/510
Other/U.S. Class
CPC Class
C07D405/12
C07D305/14
C07D409/12
C07F7/1856
Y02P20/55
Patent Type
utility
Collections
- Virginia Tech Patents [687]