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    2-debenzoyl-2-acyl taxol derivatives and method for making same

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    6002023.pdf (1.296Mb)
    Downloads: 64
    Publication Date
    1999-12-14
    Filing Date
    1997-10-15
    Inventor
    Kingston, David G. I.
    Chaudhary, Ashok G.
    Gharpure, Milind M.
    Rimoldi, John M.
    Gunatilaka, A.A. Leslie
    Metadata
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    Abstract
    The present invention relates to 2-debenzoyl-2-acyl taxol derivatives, analogues thereof and methods for making same. Compounds of the present invention include compounds having the general formula: ##STR1## wherein R.sub.1 is an alkyl or substituted alkyl; R.sub.2 is selected from the group consisting of H and C(O)R.sub.a ; R.sub.3 is selected from the group consisting of H, protecting groups, R.sub.b, and C(O)R.sub.b ; R.sub.4 is selected from the group consisting of H and C(O)R.sub.c, and wherein R.sub.a, R.sub.b, and R.sub.c are independently selected from the group consisting of alkyls, substituted alkyls, alkenyls, alkynyls, aryls, and substituted aryls; provided that R.sub.a is other than phenyl and 3-hydroxyphenyl.
    Assignee
    Virginia Tech Intellectual Properties, Inc.
    Patent Number
    6002023
    Application Number
    8950590
    Source URL
    http://pimg-fpiw.uspto.gov/fdd/23/020/060/0.pdf
    Primary/U.S. Class
    549/510
    Other/U.S. Class
    CPC Class
    C07D405/12
    C07D305/14
    C07D409/12
    C07F7/1856
    Y02P20/55
    Patent Type
    utility
    URI
    http://hdl.handle.net/10919/72404
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    • Virginia Tech Patents [687]

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