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dc.date.accessioned2016-08-24T17:54:13Z
dc.date.available2016-08-24T17:54:13Z
dc.date.issued2001-07-03
dc.identifier.urihttp://hdl.handle.net/10919/72431
dc.description.abstractA non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, cows, goats, sheep, rabbits and pigs. Concurrent expression of a gene for human von Willebrand's Factor into milk may be used to stabilize newly-secreted Factor VIII.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherUnited States Patent and Trademark Office
dc.titleTransgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor
dc.typePatent
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/54/555/062/0.pdf
dc.date.accessed2016-08-19
dc.type.dcmitypeText
dc.contributor.assigneeVirginia Polytechnic Institute and State University
dc.contributor.assigneeAmerican National Red Cross
dc.contributor.inventorDrohan, William N.
dc.contributor.inventorVelander, William H.
dc.contributor.inventorLubon, Henryk
dc.date.filed1999-03-04
dc.identifier.applicationnumber9262017
dc.subject.uspc435/69.6
dc.subject.uspcother800/14
dc.subject.uspcother800/7
dc.subject.uspcother800/15
dc.subject.uspcother800/16
dc.subject.uspcother800/17
dc.subject.uspcother800/18
dc.subject.uspcother800/25
dc.subject.cpcA01K67/0278
dc.subject.cpcA01K2207/15
dc.subject.cpcA01K2217/00
dc.subject.cpcA01K2217/05
dc.subject.cpcA01K2227/10
dc.subject.cpcA01K2227/105
dc.subject.cpcA01K2267/01
dc.subject.cpcC07K14/755
dc.subject.cpcC12N15/8509
dc.type.patenttypeutility
dc.identifier.patentnumber6255554


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