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dc.date.accessioned2016-08-24T17:54:13Z
dc.date.available2016-08-24T17:54:13Z
dc.date.issued2001-07-17
dc.identifier.urihttp://hdl.handle.net/10919/72432
dc.description.abstractAn isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mouse whey acidic protein promoter of about 4.1-4.2 kb in length extending upstream from the unique KpnI site is preferred. This mouse whey acid protein promoter is operably linked to a DNA sequence encoding a heterologous polypeptide and used to prepare transgenic non-human mammals expressing the heterologous polypeptide in their milk. Particularly efficient expression of both cDNAs and genomic DNAs encoding heterologous polypeptides was obtained in transgenic non-human mammals using this promoter, known as the long whey acidic protein promoter.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherUnited States Patent and Trademark Office
dc.titleExpression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter
dc.typePatent
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/36/623/062/0.pdf
dc.date.accessed2016-08-19
dc.type.dcmitypeText
dc.contributor.assigneeThe American Red Cross
dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.
dc.contributor.assigneeThe United States of America as represented by the Department of Health and Human Services
dc.contributor.inventorDrohan, William N.
dc.contributor.inventorVelander, William H.
dc.contributor.inventorLubon, Henryk
dc.contributor.inventorHennighausen, Lothar
dc.date.filed1999-05-28
dc.identifier.applicationnumber9321831
dc.subject.uspc536/24.1
dc.subject.uspcother800/14
dc.subject.uspcother800/7
dc.subject.uspcother800/15
dc.subject.uspcother800/16
dc.subject.uspcother800/17
dc.subject.uspcother800/18
dc.subject.cpcA01K67/0275
dc.subject.cpcA01K2207/15
dc.subject.cpcA01K2217/00
dc.subject.cpcA01K2217/05
dc.subject.cpcA01K2227/10
dc.subject.cpcA01K2227/105
dc.subject.cpcA01K2227/108
dc.subject.cpcA01K2267/01
dc.subject.cpcA61K38/00
dc.subject.cpcC07K14/75
dc.subject.cpcC07K2319/00
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dc.subject.cpcC12N15/8509
dc.subject.cpcC12N9/6464
dc.subject.cpcC12Y304/21069
dc.subject.cpcC12N2830/008
dc.type.patenttypeutility
dc.identifier.patentnumber6262336


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