Induction of tolerance by oral administration of factor VIII and treatment of hemophilia
Velander, William H.
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Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.
The United States of America as represented by the Department of Health and Human Services
Virginia Tech Intellectual Properties, Inc.
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