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    Supramolecular complexes as photoactivated DNA cleavage agents

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    Downloads: 79
    Publication Date
    2013-05-21
    Filing Date
    2009-11-02
    Inventor
    Brewer, Karen J.
    Swavey, Shawn
    Metadata
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    Abstract
    The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
    Assignee
    Virginia Tech Intellectual Properties, Inc.
    Patent Number
    8445475
    Application Number
    12610729
    Source URL
    http://pimg-fpiw.uspto.gov/fdd/75/454/084/0.pdf
    Primary/U.S. Class
    514/184
    Other/U.S. Class
    514/188
    CPC Class
    C07F15/0026
    C07F15/0053
    C07F15/008
    Patent Type
    utility
    URI
    http://hdl.handle.net/10919/72698
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