Supramolecular complexes as photoactivated DNA cleavage agents

Publication Date
2013-05-21Filing Date
2009-11-02Inventor
Brewer, Karen J.
Swavey, Shawn
Metadata
Show full item recordAbstract
The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
Assignee
Virginia Tech Intellectual Properties, Inc.
Patent Number
8445475
Application Number
12610729
Primary/U.S. Class
514/184
Other/U.S. Class
514/188
CPC Class
C07F15/0026
C07F15/0053
C07F15/008
Patent Type
utility
Collections
- Virginia Tech Patents [546]