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    Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders

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    9101573.pdf (4.456Mb)
    Downloads: 87
    Publication Date
    2015-08-11
    Filing Date
    2011-05-04
    Inventor
    Bassaganya-Riera, Josep
    Hontecillas, Raquel
    Lu, Pinyi
    Metadata
    Show full item record
    Abstract
    The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs. This includes but it is not limited to abscisic acid (ABA), ABA analogs, benzimidazophenyls, repurposed drugs or drug combinations, including thiazolidinediones (TZDs); naturally occurring compounds such as conjugated diene fatty acids, conjugated triene fatty acids, isoprenoids, and natural and synthetic agonists of peroxisome proliferator-activated receptors that activate this receptor through an alternative mechanism of action involving LANCL2 or other membrane proteins to treat or prevent the common inflammatory pathogenesis underlying type 2 diabetes, atherosclerosis, cancer, some inflammatory infectious diseases such as influenza and autoimmune diseases including but not limited to inflammatory bowel disease (Crohn's disease and Ulcerative colitis), rheumatoid arthritis, multiple sclerosis and type 1 diabetes and other chronic inflammatory conditions.
    Assignee
    Virginia Tech Intellectual Properties, Inc.
    Patent Number
    9101573
    Application Number
    13100795
    Source URL
    http://pimg-fpiw.uspto.gov/fdd/73/015/091/0.pdf
    Primary/U.S. Class
    1/1
    Other/U.S. Class
    CPC Class
    A61K31/13
    A61K31/135
    A61K31/35
    A61K31/352
    A61K31/40
    A61K31/405
    A61K31/4184
    A61K31/427
    A61K31/431
    A61K31/495
    A61K31/496
    A61K31/4985
    A61K31/517
    A61K31/545
    A61K31/55
    A61K31/56
    A61K31/57
    A61K31/65
    A61K31/655
    A61K31/704
    A61K31/7048
    A61K2300/00
    G01N33/6872
    G01N33/573
    G01N33/6875
    G01N2333/4703
    G01N2333/70567
    G01N2500/02
    G01N2500/04
    G01N2500/20
    G06F19/12
    G06F19/16
    G06F19/3456
    Y10T436/14333
    Y10T436/14555
    Y10T436/14777
    Patent Type
    utility
    URI
    http://hdl.handle.net/10919/72758
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    • Virginia Tech Patents [545]

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