Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders

Publication Date
2015-08-11Filing Date
2011-05-04Inventor
Bassaganya-Riera, Josep
Hontecillas, Raquel
Lu, Pinyi
Metadata
Show full item recordAbstract
The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component C-like (LANCL) proteins as therapeutic targets for novel classes of anti-inflammatory, immune regulatory and antidiabetic drugs. This includes but it is not limited to abscisic acid (ABA), ABA analogs, benzimidazophenyls, repurposed drugs or drug combinations, including thiazolidinediones (TZDs); naturally occurring compounds such as conjugated diene fatty acids, conjugated triene fatty acids, isoprenoids, and natural and synthetic agonists of peroxisome proliferator-activated receptors that activate this receptor through an alternative mechanism of action involving LANCL2 or other membrane proteins to treat or prevent the common inflammatory pathogenesis underlying type 2 diabetes, atherosclerosis, cancer, some inflammatory infectious diseases such as influenza and autoimmune diseases including but not limited to inflammatory bowel disease (Crohn's disease and Ulcerative colitis), rheumatoid arthritis, multiple sclerosis and type 1 diabetes and other chronic inflammatory conditions.
Assignee
Virginia Tech Intellectual Properties, Inc.
Patent Number
9101573
Application Number
13100795
Primary/U.S. Class
1/1
Other/U.S. Class
CPC Class
A61K31/13
A61K31/135
A61K31/35
A61K31/352
A61K31/40
A61K31/405
A61K31/4184
A61K31/427
A61K31/431
A61K31/495
A61K31/496
A61K31/4985
A61K31/517
A61K31/545
A61K31/55
A61K31/56
A61K31/57
A61K31/65
A61K31/655
A61K31/704
A61K31/7048
A61K2300/00
G01N33/6872
G01N33/573
G01N33/6875
G01N2333/4703
G01N2333/70567
G01N2500/02
G01N2500/04
G01N2500/20
G06F19/12
G06F19/16
G06F19/3456
Y10T436/14333
Y10T436/14555
Y10T436/14777
Patent Type
utility
Collections
- Virginia Tech Patents [545]