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dc.date.accessioned2016-08-24T17:55:28Z
dc.date.available2016-08-24T17:55:28Z
dc.date.issued2015-12-15
dc.identifier.urihttp://hdl.handle.net/10919/72766
dc.description.abstractThe present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherUnited States Patent and Trademark Office
dc.titleChimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
dc.typePatent
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/24/113/092/0.pdf
dc.date.accessed2016-08-19
dc.type.dcmitypeText
dc.contributor.assigneeIowa State University Research Foundation, Inc.
dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.
dc.contributor.inventorHalbur, Patrick G.
dc.contributor.inventorMeng, Xiang-Jin
dc.contributor.inventorFenaux, Martijn
dc.date.filed2011-10-07
dc.identifier.applicationnumber13268008
dc.subject.uspc1/1
dc.subject.cpcA61K39/12
dc.subject.cpcA61K2039/5254
dc.subject.cpcA61K2039/5256
dc.subject.cpcA61K2039/53
dc.subject.cpcA61K2039/552
dc.subject.cpcC07K14/005
dc.subject.cpcC12N7/00
dc.subject.cpcC12N2750/10022
dc.subject.cpcC12N2750/10034
dc.subject.cpcC12N2750/10061
dc.type.patenttypeutility
dc.identifier.patentnumber9211324


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