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dc.contributor.authorMirlohi, Susanen
dc.contributor.authorDuncan, Susan E.en
dc.contributor.authorHarmon, M.en
dc.contributor.authorCase, D.en
dc.contributor.authorLesser, G.en
dc.contributor.authorDietrich, Andrea M.en
dc.date.accessioned2016-09-28T18:18:33Zen
dc.date.available2016-09-28T18:18:33Zen
dc.date.issued2015-01-01en
dc.identifier.issn1432-6981en
dc.identifier.urihttp://hdl.handle.net/10919/73052en
dc.description.abstractObjectives The frequency and causes of chemosensory (taste and smell) disorders in cancer patients remain under-reported. This study examined the impact of cancer therapy on taste/ smell functions and salivary constituents in brain tumor patients. Materials and methods Twenty-two newly diagnosed patients with primary malignant gliomas underwent 6 weeks of combined modality treatment (CMD) with radiation and temozolomide followed by six monthly cycles of temozolomide. Chemosensory functions were assessed at 0, 3, 6, 10, 18, and 30 weeks with paired samples of saliva collected before and after an oral rinse with ferrous-spiked water. Iron (Fe)- induced oxidative stress was measured by salivary lipid oxidation (SLO); salivary proteins, electrolytes, and metals were determined. Parallel salivary analyses were performed on 22 healthy subjects. Results Chemosensory complaints of cancer patients increased significantly during treatment (p=0.04) except at 30 weeks. Fe-induced SLO increased at 10 and 18 weeks. When compared with healthy subjects, SLO, total protein, Na, K, Cu, P, S, and Mg levels, as averaged across all times, were significantly higher (p<0.05), whereas salivary Zn, Fe, and oral pH levels were significantly lower in cancer patients (p<0.05). Neither time nor treatment had a significant impact on these salivary parameters in cancer patients. Conclusions Impact of CMT treatment on chemosensory functions can range from minimal to moderate impairment. Analysis of SLO, metals, and total protein do not provide for reliable measures of chemosensory dysfunctions over time. Clinical relevance Taste and smell functions are relevant in health and diseases; study of salivary constituents may provide clues on the causes of their dysfunctions.en
dc.format.extent127 - 137 (11) page(s)en
dc.format.mimetypeapplication/pdfen
dc.languageEnglishen
dc.publisherSpringer Heidelbergen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348981100015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDentistry, Oral Surgery & Medicineen
dc.subjectMetallic flavoren
dc.subjectOral lipid oxidationen
dc.subjectCanceren
dc.subjectBrain tumoren
dc.subjectChemotherapyen
dc.subjectSalivaen
dc.subjectTaste and smellen
dc.subjectQUALITY-OF-LIFEen
dc.subjectMETALLIC FLAVORen
dc.subjectCANCER-PATIENTSen
dc.subjectNECK-CANCERen
dc.subjectRECEIVING CHEMOTHERAPYen
dc.subjectLIPID OXIDATIONen
dc.subjectTASTE DISORDERSen
dc.subjectBREAST-CANCERen
dc.subjectZINC-SULFATEen
dc.subjectFOOD-INTAKEen
dc.titleAnalysis of salivary fluid and chemosensory functions in patients treated for primary malignant brain tumorsen
dc.typeArticle - Refereeden
dc.contributor.departmentCivil and Environmental Engineeringen
dc.contributor.departmentFood Science and Technologyen
dc.description.notesPublished (Publication status)en
dc.title.serialClinical Oral Investigationsen
dc.identifier.doihttps://doi.org/10.1007/s00784-014-1211-8en
dc.identifier.volume19en
dc.identifier.issue1en
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS Researchen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Civil & Environmental Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International