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dc.contributor.authorGarcia, P. A.en_US
dc.contributor.authorPancotto, Theresa E.en_US
dc.contributor.authorRossmeisl, John H. Jr.en_US
dc.contributor.authorHenao-Guerrero, N.en_US
dc.contributor.authorGustafson, N. R.en_US
dc.contributor.authorDaniel, G. B.en_US
dc.contributor.authorRobertson, J. L.en_US
dc.contributor.authorEllis, T. L.en_US
dc.contributor.authorDavalos, Rafael V.en_US
dc.date.accessioned2016-11-14T15:44:35Z
dc.date.available2016-11-14T15:44:35Z
dc.date.issued2011-02-01en_US
dc.identifier.issn1533-0346en_US
dc.identifier.urihttp://hdl.handle.net/10919/73431
dc.description.abstractNon-thermal irreversible electroporation (N-TIRE) has shown promise as an ablative therapy for a variety of soft-tissue neoplasms. Here we describe the therapeutic planning aspects and first clinical application of N-TIRE for the treatment of an inoperable, spontaneous malignant intracranial glioma in a canine patient. The N-TIRE ablation was performed safely, effectively reduced the tumor volume and associated intracranial hypertension, and provided sufficient improvement in neurological function of the patient to safely undergo adjunctive fractionated radiotherapy (RT) according to current standards of care. Complete remission was achieved based on serial magnetic resonance imaging examinations of the brain, although progressive radiation encephalopathy resulted in the death of the dog 149 days after N-TIRE therapy. The length of survival of this patient was comparable to dogs with intracranial tumors treated via standard excisional surgery and adjunctive fractionated external beam RT. Our results illustrate the potential benefits of N-TIRE for in vivo ablation of undesirable brain tissue, especially when traditional methods of cytoreductive surgery are not possible or ideal, and highlight the potential radiosensitizing effects of N-TIRE on the brain.en_US
dc.format.extent73 - 83 (11) page(s)en_US
dc.languageEnglishen_US
dc.publisherAdenine Pressen_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000286483300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsIn Copyright (InC)
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectOncologyen_US
dc.subjectONCOLOGYen_US
dc.subjectElectroporationen_US
dc.subjectbrain tumoren_US
dc.subjectbrain canceren_US
dc.subjectneurosurgeryen_US
dc.subjectdogen_US
dc.subjectINDUCED BRAIN-INJURYen_US
dc.subjectABLATIONen_US
dc.subjectTUMORSen_US
dc.subjectELECTROCHEMOTHERAPYen_US
dc.subjectCHEMOTHERAPYen_US
dc.subjectIRRADIATIONen_US
dc.subjectTECHNOLOGYen_US
dc.subjectEXPRESSIONen_US
dc.subjectMANAGEMENTen_US
dc.subjectCELLSen_US
dc.titleNon-Thermal Irreversible Electroporation (N-TIRE) and Adjuvant Fractionated Radiotherapeutic Multimodal Therapy for Intracranial Malignant Glioma in a Canine Patienten_US
dc.typeArticle - Refereed
dc.description.notesPublished (Publication status)en_US
dc.title.serialTECHNOLOGY IN CANCER RESEARCH & TREATMENTen_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Engineering
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanics
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/Veterinary Medicine
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Faculty
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciences


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