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dc.contributor.authorRossmeisl, JHen_US
dc.contributor.authorAndriani, RTen_US
dc.contributor.authorCecere, Thomas E.en_US
dc.contributor.authorLahmers, Ken_US
dc.contributor.authorLeRoith, Ten_US
dc.contributor.authorZimmerman, KLen_US
dc.contributor.authorGibo, Den_US
dc.contributor.authorDebinski, Wen_US
dc.coverage.spatialSwitzerlanden_US
dc.date.accessioned2016-11-16T01:51:07Z
dc.date.available2016-11-16T01:51:07Z
dc.date.issued2015en_US
dc.identifier.urihttp://hdl.handle.net/10919/73466
dc.description.abstractThis report describes the methodology, diagnostic yield, and adverse events (AE) associated with frame-based stereotactic brain biopsies (FBSB) obtained from 26 dogs with solitary forebrain lesions. Medical records were reviewed from dogs that underwent FBSB using two stereotactic headframes designed for use in small animals and compatible with computed tomographic (CT) and magnetic resonance (MR) imaging. Stereotactic plans were generated from MR and CT images using commercial software, and FBSB performed both with (14/26) and without intraoperative image guidance. Records were reviewed for diagnostic yield, defined as the proportion of biopsies producing a specific neuropathological diagnosis, AE associated with FBSB, and risk factors for the development of AE. Postprocedural AE were evaluated in 19/26 dogs that did not proceed to a therapeutic intervention immediately following biopsy. Biopsy targets included intra-axial telencephalic masses (24/26), one intra-axial diencephalic mass, and one extra-axial parasellar mass. The median target volume was 1.99 cm(3). No differences in patient, lesion, or outcome variables were observed between the two headframe systems used or between FBSB performed with or without intraoperative CT guidance. The diagnostic yield of FBSB was 94.6%. Needle placement error was a significant risk factor associated with procurement of non-diagnostic biopsy specimens. Gliomas were diagnosed in 24/26 dogs, and meningioma and granulomatous meningoencephalitis in 1 dog each. AE directly related to FBSB were observed in a total of 7/26 (27%) of dogs. Biopsy-associated clinical morbidity, manifesting as seizures and transient neurological deterioration, occurred in 3/19 (16%) of dogs. The case fatality rate was 5.2% (1/19 dogs), with death attributable to intracranial hemorrhage. FBSB using the described apparatus was relatively safe and effective at providing neuropathological diagnoses in dogs with focal forebrain lesions.en_US
dc.format.extent20 - ? page(s)en_US
dc.languageENGen_US
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26664949en_US
dc.subjectbrain tumoren_US
dc.subjectdogen_US
dc.subjectgliomaen_US
dc.subjectneurooncologyen_US
dc.subjectneurosurgeryen_US
dc.titleFrame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Casesen_US
dc.typeArticle - Refereed
dc.description.notesPublished online (Publication status)en_US
dc.title.serialFrontiers in Veterinary Scienceen_US
dc.identifier.doihttps://doi.org/10.3389/fvets.2015.00020
dc.identifier.volume2en_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/Veterinary Medicine
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Faculty
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciences


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