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dc.contributor.authorBattogtokh, D.en
dc.contributor.authorTyson, John J.en
dc.date.accessioned2016-12-09T21:43:15Zen
dc.date.available2016-12-09T21:43:15Zen
dc.identifier.urihttp://hdl.handle.net/10919/73646en
dc.description.abstractExisting mathematical models of the shoot apical meristem (SAM) explain nucleation and confinement of a stem cell domain by Turing's mechanism, assuming that the diffusion coefficients of the activator (WUSCHEL) and inhibitor (CLAVATA) are significantly different. As there is no evidence for this assumption of differential diffusivity, we recently proposed a new mechanism based on a bistable switch model of the SAM. Here we study the bistable-switch mechanism in detail, demonstrating that it can be understood as localized switches of WUSHEL activity in individual cells driven by a non-uniform field of a peptide hormone. By comparing domain formation by Turing and bistable-switch mechanisms on a cell network, we show that the latter does not require the assumptions needed by the former, which are not supported by biological evidences.en
dc.relation.urihttp://arxiv.org/abs/1604.04643v2en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectq-bio.MNen
dc.subjectq-bio.MNen
dc.titleComparison of Domain Nucleation Mechanisms in a Minimal Model of Shoot Apical Meristemen
dc.typeArticle - Refereeden
dc.contributor.departmentBiological Sciencesen
dc.description.notes9 pages 16 figuresen
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen


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