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dc.contributor.authorLewis, Stephanie N.en_US
dc.contributor.authorBassaganya-Riera, Josepen_US
dc.contributor.authorBevan, David R.en_US
dc.date.accessioned2016-12-23T14:38:31Z
dc.date.available2016-12-23T14:38:31Z
dc.date.issued2010-01-01en_US
dc.identifier.citationStephanie N. Lewis, Josep Bassaganya-Riera, and David R. Bevan, “Virtual Screening as a Technique for PPAR Modulator Discovery,” PPAR Research, vol. 2010, Article ID 861238, 10 pages, 2010. doi:10.1155/2010/861238
dc.identifier.issn1687-4757en_US
dc.identifier.urihttp://hdl.handle.net/10919/73811
dc.description.abstractVirtual screening (VS) is a discovery technique to identify novel compounds with therapeutic and preventive efficacy against disease. Our current focus is on the in silico screening and discovery of novel peroxisome proliferator-activated receptor-gamma (PPARγ) agonists. It is well recognized that PPARγagonists have therapeutic applications as insulin sensitizers in type 2 diabetes or as anti-inflammatories. VS is a cost- and time-effective means for identifying small molecules that have therapeutic potential. Our long-term goal is to devise computational approaches for testing the PPARγ-binding activity of extensive naturally occurring compound libraries prior to testing agonist activity using ligand-binding and reporter assays. This review summarizes the high potential for obtaining further fundamental understanding of PPARγ biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results.
dc.format.extent10 page(s)en_US
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283428900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/*
dc.subjectMedicine, Research & Experimentalen_US
dc.subjectResearch & Experimental Medicineen_US
dc.subjectMEDICINE, RESEARCH & EXPERIMENTALen_US
dc.subjectACTIVATED-RECEPTOR-GAMMAen_US
dc.subjectLIGAND-BINDING DOMAINen_US
dc.subjectALPHA/GAMMA DUAL AGONISTSen_US
dc.subjectSTRUCTURE-BASED DESIGNen_US
dc.subjectCRYSTAL-STRUCTUREen_US
dc.subjectBIOLOGICAL-ACTIVITIESen_US
dc.subjectSTRUCTURAL BASISen_US
dc.subjectFATTY-ACIDSen_US
dc.subjectDIHYDROFOLATE-REDUCTASEen_US
dc.subjectMOLECULAR DOCKINGen_US
dc.titleVirtual Screening as a Technique for PPAR Modulator Discoveryen_US
dc.typeArticle - Refereed
dc.typeReview
dc.description.versionPublished (Publication status)en_US
dc.rights.holderCopyright © 2010 Stephanie N. Lewis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.title.serialPPAR RESEARCHen_US
dc.identifier.doihttps://doi.org/10.1155/2010/861238
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistry
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/University Research Institutes
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute/Researchers
pubs.organisational-group/Virginia Tech/University Research Institutes/Biocomplexity Institute/SelectedFaculty1


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Creative Commons Attribution 3.0 Unported
License: Creative Commons Attribution 3.0 Unported