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dc.contributor.authorTubio, Jose Manuel C.en_US
dc.contributor.authorTojo, Martaen_US
dc.contributor.authorBassaganyas, Laiaen_US
dc.contributor.authorEscaramis, Georgiaen_US
dc.contributor.authorSharakhov, Igor V.en_US
dc.contributor.authorSharakhova, Maria V.en_US
dc.contributor.authorTornador, Cristianen_US
dc.contributor.authorUnger, Maria F.en_US
dc.contributor.authorNaveira, Horacioen_US
dc.contributor.authorCostas, Javieren_US
dc.contributor.authorBesansky, Nora J.en_US
dc.date.accessioned2017-01-05T22:18:02Z
dc.date.available2017-01-05T22:18:02Z
dc.date.issued2011-01-24en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10919/73966
dc.description.abstractTy3/gypsy elements represent one of the most abundant and diverse LTR-retrotransposon (LTRr) groups in the Anopheles gambiae genome, but their evolutionary dynamics have not been explored in detail. Here, we conduct an in silico analysis of the distribution and abundance of the full complement of 1045 copies in the updated AgamP3 assembly. Chromosomal distribution of Ty3/gypsy elements is inversely related to arm length, with densities being greatest on the X, and greater on the short versus long arms of both autosomes. Taking into account the different heterochromatic and euchromatic compartments of the genome, our data suggest that the relative abundance of Ty3/gypsy LTRrs along each chromosome arm is determined mainly by the different proportions of heterochromatin, particularly pericentric heterochromatin, relative to total arm length. Additionally, the breakpoint regions of chromosomal inversion 2La appears to be a haven for LTRrs. These elements are underrepresented more than 7-fold in euchromatin, where 33% of the Ty3/gypsy copies are associated with genes. The euchromatin on chromosome 3R shows a faster turnover rate of Ty3/gypsy elements, characterized by a deficit of proviral sequences and the lowest average sequence divergence of any autosomal region analyzed in this study. This probably reflects a principal role of purifying selection against insertion for the preservation of longer conserved syntenyc blocks with adaptive importance located in 3R. Although some Ty3/gypsy LTRrs show evidence of recent activity, an important fraction are inactive remnants of relatively ancient insertions apparently subject to genetic drift. Consistent with these computational predictions, an analysis of the occupancy rate of putatively older insertions in natural populations suggested that the degenerate copies have been fixed across the species range in this mosquito, and also are shared with the sibling species Anopheles arabiensis.en
dc.format.extent? - ? (12) page(s)en_US
dc.languageEnglishen_US
dc.publisherPLOSen_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000286523400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMultidisciplinary Sciencesen_US
dc.subjectScience & Technology - Other Topicsen_US
dc.subjectMULTIDISCIPLINARY SCIENCESen_US
dc.subjectDROSOPHILA-MELANOGASTER GENOMEen_US
dc.subjectELEMENT COPY NUMBERen_US
dc.subjectTRANSPOSABLE ELEMENTSen_US
dc.subjectINVERSION HETEROKARYOTYPESen_US
dc.subjectGENE ASSOCIATIONSen_US
dc.subjectMDG1 LINEAGEen_US
dc.subjectDNAen_US
dc.subjectRECOMBINATIONen_US
dc.subjectSEQUENCEen_US
dc.subjectCOMPLEXen_US
dc.titleEvolutionary Dynamics of the Ty3/Gypsy LTR Retrotransposons in the Genome of Anopheles gambiaeen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.title.serialPLOS ONEen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0016328
dc.identifier.volume6en_US
dc.identifier.issue1en_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomology
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences


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Creative Commons Attribution 4.0 International (CC BY 4.0)
License: Creative Commons Attribution 4.0 International (CC BY 4.0)